Coupling trapped ion mobility spectrometry to mass spectrometry: trapped ion mobility spectrometry-time-of-flight mass spectrometry versus trapped ion mobility spectrometry-Fourier transform ion cyclotron resonance mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Lilian V ToseFrancisco Fernandez-Lima

Abstract

There is a need for fast, post-ionization separation during the analysis of complex mixtures. In this study, we evaluate the use of a high-resolution mobility analyzer with high-resolution and ultrahigh-resolution mass spectrometry for unsupervised molecular feature detection. Goals include the study of the reproducibility of trapped ion mobility spectrometry (TIMS) across platforms, applicability range, and potential challenges during routine analysis. A TIMS analyzer was coupled to time-of-flight mass spectrometry (TOF MS) and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) instruments for the analysis of singly charged species in the m/z 150-800 range of a complex mixture (Suwannee River Fulvic Acid Standard). Molecular features were detected using an unsupervised algorithm based on chemical formula and IMS profiles. TIMS-TOF MS and TIMS-FT-ICR MS analysis provided 4950 and 7760 m/z signals, 1430 and 3050 formulas using the general Cx Hy N0-3 O0-19 S0-1 composition, and 7600 and 22 350 [m/z; chemical formula; K; CCS] features, respectively. TIMS coupled to TOF MS and FT-ICR MS showed similar performance and high reproducibility. For the analysis of complex mixtures, both platforms were able to capture...Continue Reading

References

Dec 30, 2004·Analytical Chemistry·Yuzhu GuoK W Michael Siu
Jul 19, 2005·Journal of the American Society for Mass Spectrometry·Errol W Robinson, Evan R Williams
Jun 15, 2006·Analytical Chemistry·Stormy L KoenigerDavid E Clemmer
Aug 8, 2006·Journal of the American Society for Mass Spectrometry·Errol W RobinsonEvan R Williams
Jan 18, 2008·Journal of Mass Spectrometry : JMS·Abu B KanuHerbert H Hill
Jan 1, 2007·International Journal of Mass Spectrometry·Errol W RobinsonEvan R Williams
Feb 7, 2009·Journal of the American Society for Mass Spectrometry·Ruwan T KurulugamaDavid E Clemmer
Nov 13, 2009·Analytical Chemistry·Francisco A Fernandez-LimaDavid H Russell
Apr 27, 2010·Chemical Society Reviews·Charlotte UetrechtAlbert J R Heck
Sep 3, 2010·Analytical Chemistry·Rebecca S GlaskinDavid E Clemmer
Sep 6, 2011·Analytica Chimica Acta·Sergio ArmentaMarcelo Blanco
Jan 10, 2012·The Review of Scientific Instruments·F A Fernandez-LimaM A Park
Feb 2, 2012·Expert Review of Proteomics·Yueyang ZhongBrandon T Ruotolo
Sep 1, 2011·International Journal for Ion Mobility Spectrometry : Official Publication of the International Society for Ion Mobility Spectrometry·Francisco Fernandez-LimaMelvin A Park
Dec 18, 2013·Annual Review of Physical Chemistry·Thomas WyttenbachMichael T Bowers
Dec 25, 2013·Analytical Chemistry·Emily R SchenkFrancisco Fernandez-Lima
Feb 27, 2014·The Analyst·Diana Rosa HernandezFrancisco Fernandez-Lima
Dec 20, 2014·Analytical Chemistry·Jody C May, John A McLean
Sep 27, 2016·International Journal for Ion Mobility Spectrometry : Official Publication of the International Society for Ion Mobility Spectrometry·Mark E RidgewayMelvin A Park
Mar 24, 2017·Analytical Chemistry·John W T BlackburnDušan Uhrín
May 2, 2017·Environmental Science & Technology·Paolo BenigniFrancisco Fernandez-Lima

❮ Previous
Next ❯

Citations

May 28, 2019·Faraday Discussions·Dennys LeyvaFrancisco Fernandez-Lima
Mar 21, 2020·Annual Review of Analytical Chemistry·Diana Catalina Palacio LozanoMark P Barrow
Jan 26, 2021·Mass Spectrometry Reviews·Aurélie DelvauxSandra Alves
Mar 26, 2021·Mass Spectrometry Reviews·Deborah Chang, Joseph Zaia
Apr 10, 2021·Analytical Chemistry·Clement A OlanrewajuFrancisco Fernandez-Lima
May 9, 2019·Journal of the American Society for Mass Spectrometry·Christopher P RügerCarlos Afonso
Mar 8, 2019·ACS Omega·Kevin Jeanne Dit FouqueFrancisco Fernandez-Lima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.