Course and Determinants of Anosognosia in Alzheimer's Disease: A 12-Month Follow-up

Journal of Alzheimer's Disease : JAD
Oriol Turró-GarrigaJosep Lluís Conde-Sala

Abstract

Anosognosia in Alzheimer's disease (AD) has been associated with greater cognitive impairment and more behavioural and psychological symptoms of dementia (BPSD). This study examines the incidence, persistence, and remission rates of anosognosia over a 12-month period, as well as the related risk factors. This was an observational 12-month prospective study. The longitudinal sample comprised 177 patients with mild or moderate AD, and their respective caregivers. Anosognosia was assessed using the Anosognosia Questionnaire in Dementia, and we also evaluated cognitive status (Mini-Mental State Examination), functional disability (Disability Assessment in Dementia), and the presence of BPSD (Neuropsychiatric Inventory). Multinomial logistic regression was used to determine the variables associated with the incidence, persistence and remission of anosognosia. The prevalence of anosognosia was 39.5% (95% CI = 32.1-47.1) at baseline. At 12 months, incidence was 38.3% (95% CI = 28.6-48.0), persistence was 80.0% (95% CI = 69.9-90.1) and remission was 20.0% (95% CI = 9.9-30.1). The regression model identified lower age, more education, and the presence of delusions as variables associated with incidence, and more education, lower instrum...Continue Reading

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Citations

Sep 8, 2016·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Israel ContadorRobin G Morris
Mar 12, 2017·Current Neurology and Neuroscience Reports·Preeti Sunderaraman, Stephanie Cosentino
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Feb 10, 2021·Neurobiology of Aging·Jaime D MondragónUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 6, 2019·Dementia and Geriatric Cognitive Disorders Extra·Jaime D MondragónPeter Paul De Deyn

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