Course and Moderators of Hot Flash Interference during Androgen Deprivation Therapy for Prostate Cancer: A Matched Comparison

The Journal of Urology
Brian D GonzalezPaul B Jacobsen

Abstract

Many men receiving androgen deprivation therapy for prostate cancer experience hot flashes. This study aimed to describe the course of hot flash interference with time in androgen deprivation therapy recipients relative to matched prostate cancer and cancer-free controls from before the start of androgen deprivation therapy to 12 months later. We also examined demographic, clinical and genetic predictors of the impact of androgen deprivation therapy on hot flash interference. Three groups were examined, including 60 patients with prostate cancer recruited before or within 21 days of starting androgen deprivation therapy, 83 age and education matched patients with prostate cancer treated with prostatectomy only, and 86 age and education matched men with no history of cancer. Participants provided blood samples and completed the Hot Flash Related Daily Interference Scale at baseline as well as 6 and 12 months later. Androgen deprivation therapy recipients reported increasing hot flash interference with time relative to controls (p <0.001). Group differences were evident at 6 and 12 months (all p <0.001) with androgen deprivation therapy recipients reporting greater hot flash interference than controls. Several genetic polymorphis...Continue Reading

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Citations

May 5, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ashley M NelsonPaul B Jacobsen
Jun 3, 2017·Medical Oncology·Pawel J WiechnoTomasz Demkow
Feb 10, 2020·Current Oncology Reports·Risa L Wong, Alicia K Morgans

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