PMID: 9535154Apr 16, 1998Paper

Course of blood pressure within the first 12 h of hypertensive urgencies

Journal of Hypertension
M M HirschlA N Laggner

Abstract

To evaluate the course of blood pressure within 12 h of a hypertensive urgency with or without oral antihypertensive treatment prior to discharge of patients from hospital. A prospective, double-blinded, placebo-controlled and randomized clinical trial. Department of Emergency Medicine in a 2000-bed inner city hospital. Forty patients successfully treated for a hypertensive urgency with intravenous administration of urapidil. We administered 60 mg urapidil orally or placebo prior to discharge of patients from hospital and evaluated the course of blood pressure within 12 h of the urgency by use of an ambulatory blood pressure measurement unit. Mean systolic and diastolic blood pressures within the first 12 h of a hypertensive urgency and the number of hypertensive and hypotensive episodes. Mean systolic and diastolic blood pressures were significantly lower in members of the urapidil group than they were in members of the placebo group (132 +/- 14 versus 147 +/- 18 mmHg, P = 0.003; 79 +/- 12 versus 87 +/- 14 mmHg, P = 0.047, respectively). The number of hypotensive episodes was similar for these two groups (three versus one, P = 0.32), whereas the number of hypertensive episodes was significantly lower for the urapidil group (13...Continue Reading

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Citations

Jul 12, 2012·European Journal of Preventive Cardiology·Sam LiuJack M Goodman
Jan 13, 2006·The Journal of Clinical Hypertension·Seth R BenderJohn D Bisognano
Jul 14, 2001·Critical Care Clinics·W J Elliott

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