Abstract
To evaluate the course of blood pressure within 12 h of a hypertensive urgency with or without oral antihypertensive treatment prior to discharge of patients from hospital. A prospective, double-blinded, placebo-controlled and randomized clinical trial. Department of Emergency Medicine in a 2000-bed inner city hospital. Forty patients successfully treated for a hypertensive urgency with intravenous administration of urapidil. We administered 60 mg urapidil orally or placebo prior to discharge of patients from hospital and evaluated the course of blood pressure within 12 h of the urgency by use of an ambulatory blood pressure measurement unit. Mean systolic and diastolic blood pressures within the first 12 h of a hypertensive urgency and the number of hypertensive and hypotensive episodes. Mean systolic and diastolic blood pressures were significantly lower in members of the urapidil group than they were in members of the placebo group (132 +/- 14 versus 147 +/- 18 mmHg, P = 0.003; 79 +/- 12 versus 87 +/- 14 mmHg, P = 0.047, respectively). The number of hypotensive episodes was similar for these two groups (three versus one, P = 0.32), whereas the number of hypertensive episodes was significantly lower for the urapidil group (13...Continue Reading
References
Jan 1, 1988·Drugs·P A van Zwieten
Nov 1, 1985·The Journal of Pharmacy and Pharmacology·P A van ZwietenM J Thoolen
Mar 1, 1988·The American Journal of Medicine·B Littenberg, C Wolfberg
Mar 1, 1988·Clinical Pharmacokinetics·R KirstenR Haerlin
Jul 1, 1988·American Journal of Hypertension·J HueyP E MacCosbe
Jun 1, 1986·Clinical Pharmacology and Therapeutics·V L CulbertsonR L Byyny
Jan 1, 1986·European Journal of Clinical Pharmacology·G LeonettiA Zanchetti
Mar 1, 1986·Primary Care·J S Feldstein
Mar 3, 1973·British Medical Journal·S StrandgaardN A Lassen
Jul 1, 1983·Pharmacotherapy·E P MacCarthy, S S Bloomfield
Sep 1, 1984·European Heart Journal·R Y WangR P Wong
Nov 1, 1993·The American Journal of Emergency Medicine·M M HirschlA N Laggner
Jan 1, 1996·Hypertension·B ZampaglioneP Cavallo-Perin
May 1, 1996·British Journal of Anaesthesia·J G van der StroomP A van Zwieten
Dec 1, 1995·Journal of Hypertension·G ManciaA Zanchetti
Aug 1, 1997·Intensive Care Medicine·M M HirschlA N Laggner
Citations
Jul 12, 2012·European Journal of Preventive Cardiology·Sam LiuJack M Goodman
Jan 13, 2006·The Journal of Clinical Hypertension·Seth R BenderJohn D Bisognano
Jul 14, 2001·Critical Care Clinics·W J Elliott