Abstract
This prospective study examines the changes in short-term intraocular pressure (IOP) in patients with wet age-related macular degeneration (AMD) receiving intravitreal injections of 0.05 mL ranibizumab (Lucentis) in a supine position. A total of 45 eyes (45 patients, 16 M, 29 F, mean age: 78 y) received intravitreal ranibizumab injections for treatment of wet AMD (0.05 mL = 0.5 mg). The IOP was measured by Schiötz tonometry immediately preoperatively and postoperatively, and also after 3 and 10 minutes in a supine position. No history of glaucoma was present. The mean preoperative IOP was 22.4+/-5.5 mmHg in supine position. Immediately after the injection, IOP increased to 47.9+/-15.1 (range 23-82, p<0.001), with 32 eyes (71.1%) >40 and 19 eyes (42.2%) >50 mmHg. The mean difference between preoperative IOP and immediately after the injection was +25.5+/-13.6 mmHg. IOP decreased spontaneously by the first 3 minutes after operation by 12.6+/-6.0 mmHg and after 10 minutes by 21+/-9.4 mmHg. The mean difference between preoperative IOP and 10 minutes postoperatively was +4.6+/-7.0 mmHg (range: -9.3 to +25.9 mmHg, p<0.001). Eyes without a subconjunctival reflux had a higher increase in IOP than eyes with any reflux (p<0.001). IOP inc...Continue Reading
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