Course of iron parameters in HFE-hemochromatosis patients during initial treatment with erythrocytapheresis compared to phlebotomy

Journal of Clinical Apheresis
Eva Rombout-SestrienkovaDorine W Swinkels

Abstract

Current treatment for newly diagnosed patients with hereditary hemochromatosis (HH) and iron overload consist of weekly phlebotomy or less frequent and more personalized erythrocytapheresis. Previous observations during phlebotomy suggest an increase in intestinal iron uptake caused by lowering of hepcidin as a result of intensive bloodletting. It is not known whether such an effect is present or even more pronounced using erythrocytapheresis since a larger amount of iron is extracted per procedure. In this study we aimed to assess the effect of erythrocytapheresis on the course of iron parameters, with special focus on serum hepcidin. We performed a retrospective proof-of-principle observational study, comparing serum iron parameters in 12 males during the depletion phase using either phlebotomy (n = 6) or erythrocytapheresis (n = 6). Decreases in serum ferritin over time were similar for both treatments but more pronounced using erythrocytapheresis when expressed per treatment procedure. Hemoglobin did not change during erythrocytapheresis, whereas during phlebotomy decreased with 10%. Increase of erythropoietin and soluble transferrin receptor and decrease in transferrin saturation were similar for both treatments. Reduction...Continue Reading

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Citations

Oct 11, 2016·British Journal of Haematology·Eva Rombout-SestrienkovaGer H Koek
Apr 6, 2018·Nature Reviews. Disease Primers·Pierre BrissotOlivier Loréal
Jul 25, 2019·The American Journal of Gastroenterology·Kris V KowdleyVinay Sundaram
Nov 30, 2018·Pharmaceuticals·Olivier LoréalPierre Brissot
Oct 5, 2018·Journal of Clinical Imaging Science·Michaela PlaiknerBenjamin Henninger

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