Course of pregnancies in women with Cushing's disease treated by gamma-knife

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Francesco FerraùSalvatore Cannavò

Abstract

Data concerning pregnancy in women with Cushing's disease treated by gamma-knife (GK) are scanty. We present and discuss the course and outcome of five pregnancies in two women with Cushing's disease (CD), the first of whom was treated only by GK, and the second one treated by surgery, GK and ketoconazole. In the first patient, pregnancy was uneventful and full-term. During gestation, plasma ACTH, serum cortisol and 24-h urinary free cortisol (UFC) levels were steady, and always in the normal range for healthy non-pregnant individuals. The newborn was healthy and normal-weight. In the second woman, two pregnancies, occurring 3 years after GK and few months after ketoconazole withdrawal, were interrupted by spontaneous abortion or placental disruption despite normal cortisol levels. This patient became again pregnant 3 years later and delivered vaginally a healthy full-term infant. Seven months after the delivery, the patient became pregnant again and at the 39th week of gestation delivered vaginally a healthy male. Hypoprolactinemia and/or central hypothyroidism occurred in both cases. In women with CD treated by GK, pregnancy can occur. However, pregnancy is at risk even when ACTH and cortisol levels are normalized by treatmen...Continue Reading

References

Aug 29, 2003·European Journal of Endocrinology·S CannavòB Ambrosi
Jan 25, 2005·Stereotactic and Functional Neurosurgery·Jessica K DevinLewis S Blevins
Mar 15, 2005·Journal of Endocrinological Investigation·I ChiodiniA Scillitani
Apr 14, 2005·Endocrine Reviews·John R Lindsay, Lynnette K Nieman
Jun 15, 2007·Journal of Neurosurgery·Jay JagannathanMary Lee Vance
Dec 18, 2007·Neurosurgical Focus·Nelson M Oyesiku
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Lucio VilarClaudio E Kater
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Philippe CaronPhilippe Chanson

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Citations

Apr 18, 2015·Hormones : International Journal of Endocrinology and Metabolism·Alexandra ChrisoulidouJohn Wass

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