Covalent bonding of heparin to a vinyl copolymer for biomedical applications

Biomaterials
W MarconiA Piozzi

Abstract

In order to prepare polymer surfaces of vinyl type, provided with long-term haemocompatibility, a commercial ethylene-vinyl alcohol copolymer (EVAL) was covalently heparinized, employing two different bifunctional reagents (adipoil chloride and hexamethylene diisocyanate). The amount and activity of the heparin bonded to the polymer films were evaluated as a function of the concentration of the heparin solutions employed. Also, the influence exerted by the presence of various hydrophilic 'spacing arms' of different molecular weights, either neutral or provided with electrical charge, was investigated. By in vitro measurements of activated partial thromboplastin time it was seen that all the heparinized samples possessed a high degree of haemocompatibility. For the sake of comparison, heparin was also bonded ionically to EVAL functionalized by introduction of quaternary ammonium groups bonded covalently (by adipoil chloride) to the hydroxyl groups of the polymer. It was seen that the covalent immobilization system provides the polymer surfaces with a superior haemocompatibility.

Citations

Dec 31, 2002·Biomaterials·El Refaie KenawyGary E Wnek
Sep 1, 2000·Colloids and Surfaces. B, Biointerfaces·G XuY Imanishi
Nov 26, 2010·Journal of Biomaterials Science. Polymer Edition·Ying Jun DuAnthony K C Chan
Jul 27, 2001·Journal of Biomaterials Science. Polymer Edition·G C XuK Awazu
Jul 2, 2008·Chemical & Pharmaceutical Bulletin·Shin-Ichi KondoMasayuki Kuzuya
Nov 5, 2011·Acta Biomaterialia·I FrancoliniA Piozzi
Feb 22, 2011·Carbohydrate Research·Menemşe Gümüşderelioğlu, Sezin Aday
Jun 5, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Allyson K FryKaryn E Bird
Apr 26, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Saravanababu MurugesanRobert J Linhardt
Jan 5, 2011·Acta Biomaterialia·Qian YuHong Chen
Sep 8, 2015·Carbohydrate Polymers·Cristiane N CostaMarcos A S Costa
Nov 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Young Min ShinYoun-Mook Lim
Jul 27, 2017·Journal of Materials Science. Materials in Medicine·Alana Melo Dos SantosHelen Conceição Ferraz
Mar 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yoon Kyung KimWendy F Liu
Jan 22, 2011·Bioconjugate Chemistry·Yasuhide NakayamaKingo Uchida
Feb 14, 2006·Biomacromolecules·Gunaranjan ViswanathanRobert J Linhardt

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