PMID: 9549620Apr 29, 1998Paper

Covalent bonding of PMMA, PBMA, and poly(HEMA)to hydroxyapatite particles

Journal of Biomedical Materials Research
Q LiuC A van Blitterswijk

Abstract

In our earlier study, we showed that the surface hydroxyl groups of hydroxyapatite have the ability to react with organic isocyanate groups. In this study, the feasibility of grafting poly(methyl methacrylate) (PMMA), poly(n-butyl methacrylate) (PBMA), and Poly(hydroxyethyl methacrylate) [poly(HEMA)] by using the reaction of isocyanate groups with the hydroxyl groups on the surface of HA was investigated. Double bonds were introduced to the surface of HA via the coupling reaction of isocyanateoethyl methacrylate (ICEM) with HA, or through hexamethylene diisocyanate (HMDI) with hydroxyethyl methacrylate (HEMA) and HA, followed by radical polymerization in MMA, BMA, or HEMA. Infrared spectra indicated the existence of polymers on the surfaces of HA. Thermogravimetric analysis also confirmed the presence of grafted polymers on the surface of HA powder particles (20-26 wt%). The polymers gave typical PMMA, PBMA, or poly(HEMA) infrared spectra, with the exception of amide bands, a result of the coupling reaction of ICEM or HMDI with hydroxy groups of HA or HEMA. Therefore it is concluded that the polymers were chemically bonded to the surface of HA through the isocyanate groups of ICEM or HMDI.

References

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Citations

Mar 29, 2000·Journal of Biomedical Materials Research·T FuruzonoY Tamada
Aug 28, 2001·Journal of Biomedical Materials Research·Q LiuG R Baran
Feb 5, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Woo-Jae ChungSeung-Wuk Lee
Jul 30, 1999·Journal of Biomaterials Science. Polymer Edition·Y TamadaM Akashi
Feb 20, 2009·Journal of Materials Science. Materials in Medicine·Monika Supová
Aug 12, 2015·Journal of Functional Biomaterials·Sergey V Dorozhkin
Mar 29, 2011·Journal of Biomedical Materials Research. Part a·Kai WeiIck-Soo Kim
Aug 22, 2006·Biomaterials·Hongjin QiuGuillermo A Ameer
Aug 29, 2006·Biomaterials·Lorenzo MoroniClemens A van Blitterswijk
Jun 26, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis
May 7, 1998·Journal of Biomedical Materials Research·Q LiuC A van Blitterswijk
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristina L GoranovaIvan Gitsov
Apr 15, 2021·Biomedical Materials·S Ram PrasadA Jayakrishnan

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