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Covalent crosslinking of thyrotropin to thyroid plasma membrane receptors: subunit composition of the thyrotropin receptor

Archives of Biochemistry and Biophysics

Apr 1, 1986

R McQuadeS N Nayfeh

PMID: 3008661

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Abstract

The subunit composition of the thyrotropin (TSH) receptor has been characterized using the bifunctional crosslinking agent, disuccinimidyl suberate (DSS), to covalently link [125I]TSH to its receptor. Purified thyroid membranes were labeled with [125I]TSH, and the hormone-receptor compl...read more

Mentioned in this Paper

Centrifugation, Density Gradient
Thyrotropin Class in ATC
Covalent Interaction
Tissue Membrane
Hormone Receptors, Cell Surface
Glycoproteins
SDS-PAGE
Immunology
Endopeptidases
Proteolytic Enzyme
Paper Details
References
  • References27
  • Citations3
123
  • References27
  • Citations3
1

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Graves disease is common form of hyperthyroidism with a diffuse hyperplastic goiter. It is an autoimmune disorder that produces antibodies against thyroid stimulating hormone receptor. These autoantibodies activate the TSH receptor, thereby stimulating the thyroid gland and hypersecretion of thyroid hormones.Discover the latest research on Graves disease here.

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Separation of two thyrotropin binding components from porcine thyroid tissue by affinity chromatography: characterization of high and low affinity sites

Proceedings of the National Academy of Sciences of the United States of AmericaApril 1, 1982
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Covalent crosslinking of thyrotropin to thyroid plasma membrane receptors: subunit composition of the thyrotropin receptor

Archives of Biochemistry and Biophysics

Apr 1, 1986

R McQuadeS N Nayfeh

PMID: 3008661

DOI:

Abstract

The subunit composition of the thyrotropin (TSH) receptor has been characterized using the bifunctional crosslinking agent, disuccinimidyl suberate (DSS), to covalently link [125I]TSH to its receptor. Purified thyroid membranes were labeled with [125I]TSH, and the hormone-receptor compl...read more

Mentioned in this Paper

Centrifugation, Density Gradient
Thyrotropin Class in ATC
Covalent Interaction
Tissue Membrane
Hormone Receptors, Cell Surface
Glycoproteins
SDS-PAGE
Immunology
Endopeptidases
Proteolytic Enzyme

Feeds With Similar Papers

Graves Disease

Graves disease is common form of hyperthyroidism with a diffuse hyperplastic goiter. It is an autoimmune disorder that produces antibodies against thyroid stimulating hormone receptor. These autoantibodies activate the TSH receptor, thereby stimulating the thyroid gland and hypersecretion of thyroid hormones.Discover the latest research on Graves disease here.

Related Papers

Biochemical and Biophysical Research Communications

Characterization of the guinea pig adipocyte thyrotropin receptor

Biochemical and Biophysical Research CommunicationsFebruary 26, 1986
S E GennickS N Nayfeh
Proceedings of the National Academy of Sciences of the United States of America

Separation of two thyrotropin binding components from porcine thyroid tissue by affinity chromatography: characterization of high and low affinity sites

Proceedings of the National Academy of Sciences of the United States of AmericaApril 1, 1982
R W DrummondS N Nayfeh
Paper Details
References
  • References27
  • Citations3
123
  • References27
  • Citations3
1

Download from

PubMed
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