Covalent Grafting of Antifouling Phosphorylcholine-Based Copolymers with Antimicrobial Nitric Oxide Releasing Polymers to Enhance Infection-Resistant Properties of Medical Device Coatings.

Langmuir : the ACS Journal of Surfaces and Colloids
Qiaohong LiuJason Locklin

Abstract

Medical device coatings that resist protein adhesion and bacterial contamination are highly desirable in the healthcare industry. In this work, an antifouling zwitterionic terpolymer, 2-methacryloyloxyethyl phosphorylcholine-co-butyl methacrylate-co-benzophenone (BPMPC), is covalently grafted to a nitric oxide (NO) releasing antimicrobial biomedical grade copolymer of silicone-polycarbonate-urethane, CarboSil, to significantly enhance the biocompatibility, nonspecific protein repulsion and infection-resistant properties. The NO donor embedded into CarboSil is S-nitroso-N-acetylpenicillamine (SNAP) and covalent grafting of the BPMPC is achieved through rapid UV-cross-linking, providing a stable, hydrophilic coating that has excellent durability over a period of several weeks under physiological conditions. The protein adsorption test results indicate a significant reduction (∼84-93%) of protein adhesion on the test samples compared to the control samples. Bacteria tests were also performed using the common nosocomial pathogen, Staphylococcus aureus. Test samples containing both NO donor and BPMPC show a 99.91 ± 0.06% reduction of viable bacteria when compared to control samples. This work demonstrates a synergistic combination o...Continue Reading

References

Dec 1, 1991·Journal of Biomedical Materials Research·W R GombotzA S Hoffman
Apr 11, 2002·Chemical Reviews·Peng George WangAdam J Janczuk
Apr 1, 2004·Analytical Chemistry·Shuwen HuNancy L Allbritton
Oct 21, 2004·Journal of the American Chemical Society·Mi-Kyoung ParkRigoberto C Advincula
Aug 29, 2006·Chemical Society Reviews·Evan M Hetrick, Mark H Schoenfisch
Nov 17, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Zheng ZhangShaoyi Jiang
Apr 12, 2007·Biomacromolecules·El-Refaie KenawyRoy Broughton
Jun 13, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Khalil Abu-RabeahRobert S Marks
Aug 12, 2009·Journal of Virological Methods·Thomas BrandstetterJürgen Rühe
Dec 31, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Christine BunteJürgen Rühe
Feb 5, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ai T NguyenHan Zuilhof
Nov 2, 2009·Macromolecular Rapid Communications·Christine Bunte, Jürgen Rühe
Feb 22, 2012·Nitric Oxide : Biology and Chemistry·Benjamin J PrivettMark H Schoenfisch
Apr 4, 2012·Antioxidants & Redox Signaling·Katarzyna A Broniowska, Neil Hogg
Mar 29, 2014·The New England Journal of Medicine·Shelley S MagillUNKNOWN Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team
Apr 16, 2014·ACS Applied Materials & Interfaces·Harihara S SundaramShaoyi Jiang
Jun 24, 2014·ACS Applied Materials & Interfaces·Carlos Diaz BlancoTzanko Tzanov
Nov 5, 2014·Advanced Materials·Qing Shao, Shaoyi Jiang
Feb 17, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Elizabeth J BrisboisHitesh Handa
May 15, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Peng-Fei RenZhi-Kang Xu
May 29, 2015·Clinical Microbiology Reviews·Steven Y C TongVance G Fowler
Jul 24, 2015·ACS Applied Materials & Interfaces·Xiaojie LinKazuhiko Ishihara
Sep 17, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adoracion Pegalajar-JuradoMelissa M Reynolds
Dec 6, 2016·Acta Biomaterialia·Priyadarshini SinghaHitesh Handa
May 1, 2001·Langmuir : the ACS Journal of Surfaces and Colloids·R Erik HolmlinGeorge M Whitesides

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Citations

Mar 7, 2020·Macromolecular Rapid Communications·Wei SunHong Chen
Feb 10, 2019·Journal of Biomedical Materials Research. Part a·Priyadarshini SinghaHitesh Handa
May 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zahra SadrearhamiCyrille Boyer
May 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yang ZhouMark E Meyerhoff
Jan 13, 2021·ACS Infectious Diseases·Rashin Namivandi-ZangenehCyrille Boyer
Dec 29, 2020·Frontiers in Chemistry·Alexander H Jesmer, Ryan G Wylie
Aug 27, 2018·Colloids and Surfaces. B, Biointerfaces·Zhuangsheng Lin, Julie M Goddard
Jan 5, 2019·ACS Applied Materials & Interfaces·Marcus J GoudieHitesh Handa
Oct 23, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Richen LiKaren L Wooley
Jul 27, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·André Laschewsky, Axel Rosenhahn
Apr 10, 2020·ACS Applied Materials & Interfaces·Ryan DevineHitesh Handa
Aug 28, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Fuqiang LiuPaul K Chu
Nov 25, 2021·ACS Applied Materials & Interfaces·Mark GarrenHitesh Handa

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