Covalent layer-by-layer assembly of polyethyleneimine multilayer for antibacterial applications

Journal of Biomedical Materials Research. Part a
Tao He, Vincent Chan

Abstract

Polyelectrolyte multilayer film (PMF) is conventionally fabricated by the layer-by-layer (LBL) assembly of a pair of oppositely charged polyelectrolytes on a substrate through electrostatic attractions. However, the lack of long-term stability of PMF under physiological conditions limits its application as antimicrobial coating in medical devices. In this study, a stable PMF composed of only polyethyleneimine (PEI) was constructed by covalent LBL deposition. First, the specific buildup of PEI during covalent LBL assembly was validated by UV-Vis absorption spectroscopy and atomic force microscopy. Second, silver (Ag) nanoparticles were incorporated into PEI multilayers through in situ reduction of Ag(+) by the pre-absorption of NaBH(4). It was also shown that the mass of Ag nanoparticle can be controlled by varying multilayer thickness and loading cycles. Bacterial live/dead assay showed that the PEI multilayers effectively killed Staphylococcus aureus and Escherichia coli upon contact formation. The inclusion of Ag nanoparticles in (PEI) film not only enhanced the antimicrobial property against adherent bacteria but also led to the inhibition of the bacteria growth in suspended culture via the long-term release of Ag(+) into th...Continue Reading

References

Jan 1, 1992·Biomaterials·N P DesaiJ A Hubbell
Aug 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E Rupp, G L Archer
Jan 1, 1994·Progress in Medicinal Chemistry·A D Russell, W B Hugo
May 1, 1996·Critical Reviews in Toxicology·M A Hollinger
Jul 13, 2002·Biotechnology and Bioengineering·Joerg C TillerAlexander M Klibanov
Sep 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·C PicartP Lavalle
Mar 6, 2003·Journal of the American Chemical Society·Serhiy Malynych, George Chumanov
Oct 31, 2003·Biotechnology Letters·Jian LinAlexander M Klibanov
May 26, 2004·Journal of Colloid and Interface Science·Ivan Sondi, Branka Salopek-Sondi
Nov 3, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Mary E RobbinsMark H Schoenfisch
Mar 15, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·S M Iconomopoulou, G A Voyiatzis
Apr 2, 2005·Biotechnology and Bioengineering·Nebojsa M MilovićAlexander M Klibanov
Apr 13, 2005·The Journal of Hospital Infection·S L PercivalD Russell
Jul 5, 2005·Biomaterials·Olivier EtienneChristophe Egles
Oct 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Daeyeon LeeMichael F Rubner
Dec 14, 2005·Journal of Biomedical Materials Research. Part a·Z ShiW Wang
Dec 28, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Milena IgnatovaChristine Jérôme
Jun 3, 2006·Chemistry : a European Journal·Dorota I RozkiewiczDavid N Reinhoudt
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kris C WoodPaula T Hammond
Nov 17, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Zhi LiMichael F Rubner
Feb 14, 2007·Journal of Biomedical Materials Research. Part a·Chrysanty TedjoVincent Chan
Sep 15, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Chi-Jen ChungJu-Liang He
Jan 1, 1994·Metal-based Drugs·J L Clement, P S Jarrett
Mar 18, 2010·Chemical Communications : Chem Comm·Uttam MannaSatish Patil

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Citations

Jan 20, 2012·ACS Applied Materials & Interfaces·Jens LangeckerBarbara Hanselmann
Oct 20, 2011·Chemical Reviews·Steven R Meyers, Mark W Grinstaff
Aug 15, 2014·International Journal of Molecular Sciences·Jiri GalloCalin S Moucha
Apr 25, 2012·Journal of Biomedical Materials Research. Part a·Achala de MelAlexander M Seifalian
Oct 8, 2011·Colloids and Surfaces. B, Biointerfaces·Coskun SilanNurettin Sahiner
Nov 26, 2014·Annual Review of Food Science and Technology·Luis J BastarracheaJulie M Goddard
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Arzu PalantokenSabriye Piskin
Sep 30, 2015·Biomaterials Science·Xiaoying Zhu, Xian Jun Loh
May 6, 2016·Polymer Chemistry·Ignacio InsuaFrancisco Fernandez-Trillo
Sep 19, 2018·Journal of Biomaterials Applications·Steffi WiesenmuellerKatja Mercer-Chalmers Bender
Mar 30, 2011·The International Journal of Artificial Organs·Catrin StrobelBritt Wildemann
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Syafiqah SaidinAbdullah Sharaf Saleh Al-Hammadi
Oct 4, 2020·Advances in Colloid and Interface Science·Changwen ZhaoWantai Yang
Apr 30, 2021·ACS Applied Materials & Interfaces·Jiaying LiWiebe M de Vos
Feb 14, 2018·ACS Applied Materials & Interfaces·Shanshan GuoKoon Gee Neoh
Aug 26, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Sinem UlusanIrem Erel-Goktepe

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