PMID: 6625758Jul 1, 1983Paper

Covalent modifications of chromosomal proteins during aging

Archives of Gerontology and Geriatrics
M K Thakur

Abstract

Covalent modifications of proteins introduce negative or positive charges into the molecules and thereby cause alterations in the ionic interactions of protein-protein or DNA-protein complexes. Whereas modifications of histones largely affect the organization of chromatin, those of non-histone proteins are believed to be involved in the expression of genes. These modifications during aging have been reviewed here. The available data suggest that the extent of covalent modifications of histones and non-histone chromosomal (NHC) proteins change during aging and such modifications may have an important role in the differential expression of genes at different phases of life span of an organism.

References

Dec 2, 1977·Science·R Uy, F Wold
Jan 1, 1979·Annual Review of Biochemistry·I Isenberg
Aug 22, 1979·Biochimica Et Biophysica Acta·A R O'Meara, S F Pochron
Dec 21, 1977·Biochemical and Biophysical Research Communications·M S Kanungo, M K Thakur
Apr 14, 1978·Biochemical and Biophysical Research Communications·M K ThakurM S Kanungo
Oct 1, 1978·Experimental Cell Research·S F PochronM J Kurtz
Oct 1, 1978·Mechanisms of Ageing and Development·M PetricevicL Messineo
Jul 1, 1977·Journal of Gerontology·G StramentinoliS Algeri
Oct 10, 1975·Science·A Ruiz-CarrilloV G Allfrey
Sep 1, 1975·Journal of Theoretical Biology·M S Kanungo
Mar 1, 1974·Science·G S SteinL J Kleinsmith
Sep 1, 1974·Journal of Neurochemistry·J A Duerre, C T Lee
Mar 1, 1974·Mechanisms of Ageing and Development·A Comfort
Aug 21, 1972·Biochemical and Biophysical Research Communications·J M Ryan, V J Cristofalo
Dec 22, 1972·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·Y H Oh, R A Conard
Jun 20, 1973·Biochimica Et Biophysica Acta·W K Paik, S Kim
Apr 1, 1972·Experimental Gerontology·H A Johnson, S Erner
Feb 1, 1972·Archives of Biochemistry and Biophysics·P ByvoetB J Noland
Oct 1, 1972·Developmental Biology·R BalhornR Chalkley
Jan 1, 1970·Canadian Journal of Biochemistry·G H AdamsJ M Neelin
Mar 1, 1968·The Biochemical Journal·D M Phillips
Jun 3, 1967·Nature·C J Epstein, E A Gatens
Oct 1, 1980·Experimental Aging Research·J A Meacham
Apr 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·L E ORGEL

Citations

Dec 1, 1991·Aging : Clinical and Experimental Research·S Prasad, M K Thakur
Dec 1, 1984·Mechanisms of Ageing and Development·Z A Medvedev
Oct 31, 1984·Mechanisms of Ageing and Development·M K Thakur
Mar 31, 1990·Mechanisms of Ageing and Development·M K Thakur, S Prasad
Jan 1, 1993·Mechanisms of Ageing and Development·M K ThakurY Natori
Sep 30, 1996·Mechanisms of Ageing and Development·A Krześlak, A Lipińska
Dec 24, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·W J Poly
Jan 1, 1988·Journal of Community Health Nursing·C L CoxJ A Sullivan

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