Covariance among age, spinal p38 MAP kinase activation and allodynia

The Journal of Pain : Official Journal of the American Pain Society
Camilla I SvenssonLinda Sorkin

Abstract

This study examined effects of age (young rats, approximately 35 days, vs mature rats, approximately 75-110 days) on spinal nerve ligation (SNL)-induced tactile allodynia and phosphorylation of p38 (as measured by phospho-p38 MAP kinase [P-p38]) in dorsal root ganglia and spinal cord. Effects of SNL combined with spinal nerve transection also were assessed. Mature rats displayed milder SNL-induced allodynia than young rats. Addition of spinal nerve transection distal to the ligation in older animals resulted in an allodynia comparable to that seen in young animals. In DRG, both groups displayed early (5 h) and late (10 days) peaks in P-p38 following surgery as compared to naïve rats. Tight nerve ligation plus transection had no additional effect on P-p38 levels in DRG. In spinal cord, young rats had increased levels of P-p38 from 5 h to 3 days after SNL. Phosphorylated p38 levels then decreased, with a second peak at 10 days. In contrast, spinal cord from mature rats showed less early p38 phosphorylation, although they also displayed a late 10-day peak. Addition of a transection to the ligation produced restoration of the early peak along with intensification of allodynia. Alterations of spinal P-p38 at early time points thus s...Continue Reading

References

Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Nov 8, 2001·European Journal of Pharmacology·M Zimmermann
May 8, 2003·The Journal of Pharmacology and Experimental Therapeutics·Vasudeva RaghavendraJoyce A DeLeo
Feb 11, 2004·Experimental Neurology·Robert R MyersW Marie Campana
Aug 21, 2004·Journal of Neurotrauma·Young Seob GwakClaire E Hulsebosch

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Citations

May 13, 2008·The Journal of Pain : Official Journal of the American Pain Society·Tally M Largent-MilnesTodd W Vanderah
Jul 2, 2008·Experimental Neurology·Eric D CrownClaire E Hulsebosch
Jun 3, 2020·Life Sciences·Lijia MaiWenguo Fan

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