Coverage and power in genomewide association studies.

American Journal of Human Genetics
Eric Jorgenson, John S Witte

Abstract

The ability of genomewide association studies to decipher genetic traits is driven in part by how well the measured single-nucleotide polymorphisms "cover" the unmeasured causal variants. Estimates of coverage based on standard linkage-disequilibrium measures, such as the average maximum squared correlation coefficient (r2), can lead to inaccurate and inflated estimates of the power of genomewide association studies. In contrast, use of the "cumulative r2 adjusted power" measure presented here gives more-accurate estimates of power for genomewide association studies.

References

Jun 19, 2001·American Journal of Human Genetics·J K Pritchard, M Przeworski
Feb 28, 2002·American Journal of Epidemiology·W James Gauderman
Aug 14, 2003·American Journal of Human Genetics·Jeffrey D Wall, Jonathan K Pritchard
Jan 22, 2004·Human Molecular Genetics·Xiayi KePanos Deloukas
Oct 23, 2004·Science·UNKNOWN ENCODE Project Consortium
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium

❮ Previous
Next ❯

Citations

Aug 30, 2007·BMC Genetics·Robert J Klein
Jul 31, 2007·Future Oncology·Eric Jorgenson, John S Witte
May 15, 2009·Genes and Immunity·D L ArmstrongC O Jacob
Oct 24, 2007·Nature Genetics·UNKNOWN Wellcome Trust Case Control ConsortiumMathew Brown
May 23, 2006·Nature Genetics·Jeffrey C Barrett, Lon R Cardon
Mar 20, 2010·Annual Review of Public Health·John S Witte
Oct 19, 2006·Nature Reviews. Genetics·Eric Jorgenson, John S Witte
Jun 15, 2007·European Journal of Human Genetics : EJHG·Zongli XuJack A Taylor
Jul 24, 2012·Rheumatic Diseases Clinics of North America·Noam Jacob, Chaim O Jacob
May 30, 2009·Drug Discovery Today·Xin ChenSiu Tim Cheung
Jun 24, 2008·Theoretical Population Biology·Jenna M VanLiere, Noah A Rosenberg
Aug 16, 2008·Annals of Human Genetics·B HanE Eskin
Feb 14, 2008·Genetic Epidemiology·Chun LiWei Zheng
Oct 1, 2011·Journal of Periodontal Research·M FolwacznyJ Glas
Dec 21, 2012·The Prostate·Mitchell J MachielaUNKNOWN National Cancer Institute Breast and Prostate Cancer Cohort Consortium
Oct 8, 2013·PloS One·Hui DaiFeng Chen
Feb 1, 2014·Evolution, Medicine, and Public Health·Michael D EdgeNoah A Rosenberg
Aug 30, 2006·Annals of Medicine·Elina SuviolahtiPäivi Pajukanta
Jul 31, 2012·Human Genetics·Hao MeiGerald S Berenson
Aug 28, 2013·G3 : Genes - Genomes - Genetics·Sarah C NelsonCathy C Laurie
Oct 10, 2018·Proceedings of the National Academy of Sciences of the United States of America·Eric JorgensonStephen K Van Den Eeden
Jul 8, 2010·Statistical Science : a Review Journal of the Institute of Mathematical Statistics·Duncan C ThomasDaniel O Stram

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.