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Coverage-dependent bias creates the appearance of binary splicing in single cells

bioRxiv

Dec 20, 2019

Carlos F. Buen Abad NajarLiana F. Lareau

Abstract

Single cell RNA sequencing provides powerful insight into the factors that determine each cell’s unique identity, including variation in transcription and RNA splicing among diverse cell types. Previous studies led to the surprising observation that alternative splicing outcomes among s...read more

Mentioned in this Paper

Analysis
Transcription, Genetic
Gene Expression
Alternative Splicing
RNA Splicing
Cytology
Sequence Determinations, RNA
Patterns
Laboratory mice
Simulation
292
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Coverage-dependent bias creates the appearance of binary splicing in single cells

bioRxiv

Dec 20, 2019

Carlos F. Buen Abad NajarLiana F. Lareau

PMID: 990883256

DOI: 10.1101/2019.12.19.883256

Abstract

Single cell RNA sequencing provides powerful insight into the factors that determine each cell’s unique identity, including variation in transcription and RNA splicing among diverse cell types. Previous studies led to the surprising observation that alternative splicing outcomes among s...read more

Mentioned in this Paper

Analysis
Transcription, Genetic
Gene Expression
Alternative Splicing
RNA Splicing
Cytology
Sequence Determinations, RNA
Patterns
Laboratory mice
Simulation
292

Similar Papers Found In These Feeds

RNA Splicing (Keystone)

The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. Discover the latest research on RNA splicing and co-transcriptional splicing in this feed.

Human Cell Atlas Consortium

The aim of the Human Cell Atlas is to build reference maps of all human cells in order to enhance our understanding of health and disease. Follow the latest research from the Human Cell Atlas Consortium here.

Related Papers

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