COVID-19 and its implications for thrombosis and anticoagulation.

Blood
Jean M Connors, Jerrold H Levy

Abstract

Severe acute respiratory syndrome coronavirus 2, coronavirus disease 2019 (COVID-19)-induced infection can be associated with a coagulopathy, findings consistent with infection-induced inflammatory changes as observed in patients with disseminated intravascular coagulopathy (DIC). The lack of prior immunity to COVID-19 has resulted in large numbers of infected patients across the globe and uncertainty regarding management of the complications that arise in the course of this viral illness. The lungs are the target organ for COVID-19; patients develop acute lung injury that can progress to respiratory failure, although multiorgan failure can also occur. The initial coagulopathy of COVID-19 presents with prominent elevation of D-dimer and fibrin/fibrinogen-degradation products, whereas abnormalities in prothrombin time, partial thromboplastin time, and platelet counts are relatively uncommon in initial presentations. Coagulation test screening, including the measurement of D-dimer and fibrinogen levels, is suggested. COVID-19-associated coagulopathy should be managed as it would be for any critically ill patient, following the established practice of using thromboembolic prophylaxis for critically ill hospitalized patients, and s...Continue Reading

References

Apr 28, 2004·Emerging Infectious Diseases·Elisa VicenziMassimo Clementi
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephanie A SmithJames H Morrissey
May 30, 2007·Biochemical and Biophysical Research Communications·Lanying DuBo-Jian Zheng
Sep 20, 2008·Nature Reviews. Immunology·Daniel RittirschPeter A Ward
Aug 21, 2009·Journal of Thrombosis and Haemostasis : JTH·S S SmythUNKNOWN 2009 Platelet Colloquium Participants
Jul 30, 2011·Journal of Thrombosis and Haemostasis : JTH·N A Zakai, L A McClure
Dec 12, 2012·Nature Reviews. Immunology·Bernd Engelmann, Steffen Massberg
Feb 6, 2013·Journal of Thrombosis and Haemostasis : JTH·H WadaUNKNOWN The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis
Aug 21, 2013·European Journal of Internal Medicine·Giuseppe LippiGianfranco Cervellin
Oct 19, 2013·Thrombosis and Haemostasis·Tzu-Fei WangBrian F Gage
Feb 15, 2014·World Journal of Cardiology·Olli Arjamaa
Feb 15, 2014·World Journal of Clinical Cases·Federico GobbiZeno Bisoffi
Dec 19, 2014·Blood·Jerrold H Levy, Lawrence T Goodnough
Jul 13, 2016·Shock·Travis J GouldUNKNOWN Canadian Critical Care Translational Biology Group
Oct 8, 2016·Advances in Virus Research·R J G HulswitB-J Bosch
Aug 23, 2017·Vaccine·Daniel S LaytonAndrew G D Bean
Dec 5, 2017·Annals of Intensive Care·Xavier DelabrancheFerhat Meziani
Dec 5, 2017·Anesthesiology·Jerrold H LevyNigel S Key
Dec 20, 2017·Blood·Marcel Levi, Marie Scully
Dec 21, 2017·Critical Care Medicine·Fabrizio SemeraroLuciano Gattinoni
Apr 8, 2018·The Annals of Thoracic Surgery·Christopher J PannucciThomas K Varghese
May 31, 2018·Journal of Thrombosis and Haemostasis : JTH·K SuzukiUNKNOWN Subcommittee on Disseminated Intravascular Coagulation
Sep 11, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Toshiaki IbaJerrold H Levy
Sep 30, 2018·Intensive Care Medicine·Julie Helms, UNKNOWN ICM Junior Editors
Dec 26, 2018·Journal of Thrombosis and Haemostasis : JTH·T Iba, J H Levy
Jan 9, 2019·Journal of Thrombosis and Haemostasis : JTH·T IbaUNKNOWN Subcommittee on Disseminated Intravascular Coagulation
Mar 23, 2019·Blood·Denis F NoubouossieNigel S Key
May 7, 2019·Thrombosis Research·Toshiaki IbaUNKNOWN Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis
May 18, 2019·Journal of Thrombosis and Haemostasis : JTH·Toshiaki IbaUNKNOWN Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis
May 28, 2019·Journal of Clinical Medicine·Toshiaki IbaTheodore E Warkentin
Aug 15, 2019·Journal of Thrombosis and Haemostasis : JTH·Toshiaki IbaUNKNOWN Scientific and Standardization Committee on DIC, and the Scientific and Standardization Committee on Perioperative and Criti
Sep 7, 2019·Critical Care : the Official Journal of the Critical Care Forum·Kazuma YamakawaToshiaki Iba
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Ning TangZiyong Sun
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19

❮ Previous
Next ❯

Citations

May 16, 2020·Physiological Reviews·Andrew B Barker, Brant M Wagener
May 20, 2020·British Journal of Haematology·Isabel FarmerTullie Yeghen
May 15, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Job Harenberg, Emmanuel Favaloro
Jun 11, 2020·Journal of Clinical Medicine·Jacek BajRyszard Maciejewski
Jun 4, 2020·Clinics·Ana Cristina Breithaupt-FaloppaLuiz Felipe Pinho Moreira
Jun 3, 2020·British Journal of Haematology·Joseph A HippensteelSarah E Jolley
Jun 26, 2020·Paediatrics and International Child Health·Nipunie Rajapakse, Devika Dixit
May 27, 2020·British Journal of Haematology·Yvonne DanielMichael J Shattock
Jun 24, 2020·Emerging Microbes & Infections·Jean-Marie BerthelotFrédéric Lioté
Jun 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judy ChenDaniel R Goldstein
Jun 12, 2020·Journal of Thrombosis and Haemostasis : JTH·María Isabel Rivas-PollmarVictor Jiménez-Yuste
Jul 9, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Aikaterini FitsioriMaria Isabel Vargas
Jul 10, 2020·Leukemia & Lymphoma·Alain MinaLeonidas C Platanias
Jul 11, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Michael C OlsonPerry J Pickhardt
Jul 22, 2020·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Zachary SanfordDavid J Kaczorowski
Jun 27, 2020·Epilepsia·Loïc Le GuennecSophie Demeret
Jun 27, 2020·Circulation Research·James D McFadyenKarlheinz Peter
Jul 20, 2020·Diagnosis·Massimo FranchiniGiancarlo Maria Liumbruno
Aug 1, 2020·The Medical Journal of Australia·Sarah ZamanRavinay Bhindi
May 27, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hakeem YusuffDaniel Brodie
Jul 1, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Daniel G CyrSolly E Elmann
Jul 16, 2020·Journal of Thrombosis and Haemostasis : JTH·Christophe NougierYesim Dargaud
Jul 7, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kelly SmithMichael P Krajewski
Aug 14, 2020·The Tohoku Journal of Experimental Medicine·Diana Ornelas-Ricardo, Ana Rebeca Jaloma-Cruz
May 30, 2020·Critical Care Medicine·Toshiaki IbaJecko Thachil
Aug 23, 2020·Thrombosis and Haemostasis·Rushad PatellNigel S Key
May 31, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jasper Fuk-Woo ChanKwok-Yung Yuen
Jul 22, 2020·Journal of Thrombosis and Haemostasis : JTH·Rushad PatellJeffrey I Zwicker
Jul 28, 2020·Journal of Travel Medicine·Salim Parker, Ozayr Mahomed
Aug 25, 2020·Thrombosis and Haemostasis·Upendra K KatneniChava Kimchi-Sarfaty
Jul 14, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel MackmanNigel S Key
Aug 28, 2020·Hospital Pediatrics·Rebekah DiamondMirna Giordano
Sep 4, 2020·BMJ Case Reports·Abigail Anness, Farah Siddiqui
Jul 20, 2020·The American Journal of Tropical Medicine and Hygiene·Marcus Tulius T SilvaAbelardo Q-C Araujo
Sep 6, 2020·Journal of Thrombosis and Thrombolysis·Seshadri Reddy VarikasuvuNaveen Dutt
Sep 10, 2020·PLoS Pathogens·Lien Anh Ha DoPaul V Licciardi
Sep 10, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Romeo Gabriel Mihaila, Marius Dragos Mihaila
Jun 24, 2020·Blood·Bhanu Kanth ManneRobert A Campbell
Aug 9, 2020·Blood·Rushad PatellJeffrey I Zwicker
Sep 4, 2020·The Oncologist·Evan C ChenJean M Connors

❮ Previous
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