COVID-19 and neurological disorders: are neurodegenerative or neuroimmunological diseases more vulnerable?

Journal of Neurology
Luigi Ferini-Strambi, Maria Salsone

Abstract

Neurological disorders and coronavirus 2019 (COVID-19) pandemic are two conditions with a recent well-documented association. Intriguing evidences showed that COVID-19 infection can modify clinical spectrum of manifested neurological disorders but also it plays a crucial role in the development of future diseases as long-tem consequences. In this viewpoint review, we aimed to assess the vulnerability to SARS-CoV-2 infection and development of COVID-19 among neurological disorders. With this in mind, we tested the hypothesis that age rather than neuropathology itself could be decisive in neurodegenerative diseases such as Parkinson's disease, whereas neuropathology rather than age may be critical in neuroimmunological diseases such as Multiple Sclerosis. Highlighting the role of potential susceptibility or protection factors from this disastrous infection, we also stratify the risk for future neurodegeneration.

References

Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·E FazziniS Fahn
Dec 18, 2001·International Journal of Geriatric Psychiatry·C G LyketsosJ C Breitner
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Sep 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marc F DoobayEric Lazartigues
Sep 4, 2007·Protein Science : a Publication of the Protein Society·Jaume TorresXiandi Gong
Apr 3, 2009·Brain : a Journal of Neurology·Josa M FrischerHans Lassmann
May 15, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rick C HelmichIvan Toni
Mar 9, 2011·Neurochemical Research·Susan A AustinColin K Combs
Dec 18, 2013·Lancet·Nick C Fox, Ronald C Petersen
Apr 24, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Trevor W Robbins, Roshan Cools
Oct 12, 2017·The New England Journal of Medicine·Edward R Marcantonio
Oct 27, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Krista L LanctôtBrendon Boot
Mar 20, 2018·Advances in Virus Research·Victor M CormanChristian Drosten
Apr 1, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·José Maria Andreas WijnandsHelen Tremlett
Apr 9, 2018·Parkinsonism & Related Disorders·Taisuke JoYasuhiro Yamauchi
Dec 6, 2019·Neurology·Jaime M Hatcher-MartinRaghav Govindarajan
Feb 20, 2020·Multiple Sclerosis and Related Disorders·R PerssonS S Jick
Feb 28, 2020·Journal of Medical Virology·Yan-Chao LiTsutomu Hashikawa
Mar 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rita MarreirosCarsten Korth
Apr 3, 2020·Lancet·Huali WangXin Yu
Apr 7, 2020·Journal of Parkinson's Disease·Rick C Helmich, Bastiaan R Bloem
Apr 16, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Alice LippiAnita Krisko
Apr 18, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·J Matías-GuiuJ A Matias-Guiu
Apr 19, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Simona BonavitaLuigi Lavorgna
Apr 19, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Shweta PrasadPramod Kumar Pal
Apr 21, 2020·Brain, Behavior, and Immunity·Michael J Butler, Ruth M Barrientos
Apr 23, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzSheng Luo
Apr 26, 2020·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Eric E BrownBenoit H Mulsant
Apr 30, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Angelo AntoniniK Ray Chaudhuri
May 4, 2020·Lancet Neurology·Maria Pia Sormani, UNKNOWN Italian Study Group on COVID-19 infection in multiple sclerosis
May 7, 2020·The Egyptian Journal of Neurology, Psychiatry and Neurosurgery·Salman MansoorNauman Saleem Siddiqui
May 7, 2020·Movement Disorders Clinical Practice·A Jon StoesslMarcelo Merello
May 7, 2020·Movement Disorders Clinical Practice·Stella M PapaUNKNOWN MDS‐Scientific Issues Committee
May 10, 2020·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gianluca IsaiaMario Bo
May 11, 2020·Multiple Sclerosis and Related Disorders·Fahimeh Haji AkhoundiAbdorreza Naser Moghadasi

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Citations

Oct 30, 2020·Journal of Neurotrauma·Steven T DeKoskyRonald L Hayes
Jan 23, 2021·NPJ Parkinson's Disease·Megan P FeeneyRoy N Alcalay
Jan 21, 2021·Biomedical Materials·Qin ZhangWeimin Li
Mar 10, 2021·NPJ Parkinson's Disease·Agnes LangerHeidemarie Zach
Mar 26, 2021·Molecular Neurobiology·Mahnaz NorouziParvaneh Nikpour
May 14, 2021·Dementia and Neurocognitive Disorders·Hojin ChoiYong S Shim
Jun 26, 2021·Neurology. Neuroimmunology and Neuroinflammation·Georgina ArrambideJosé E Meca-Lallana
Jul 20, 2021·Frontiers in Immunology·Rakhee K RamakrishnanImad M Tleyjeh
Aug 14, 2021·Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen·Nicola LitkeMichel Wensing
Aug 21, 2021·American Journal of Physical Medicine & Rehabilitation·Min-Yong LeeHan Gil Seo
Aug 26, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Maryam MozafarHakimeh Zali
Aug 20, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Nina N KleinebergUNKNOWN LEOSS Study Group
Oct 15, 2021·Journal of Neuroinflammation·Shawn Hayley, Hongyu Sun
Jul 20, 2021·The Journal of Neuropsychiatry and Clinical Neurosciences·Theodora A ManolisAntonis S Manolis

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