COVID-19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases

Journal of Cellular Physiology
Iyer MahalaxmiVellingiri Balachandar

Abstract

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent of novel coronavirus 2019 (COVID-19), has kept the globe in disquiets due to its severe life-threatening conditions. The most common symptoms of COVID-19 are fever, sore throat, and shortness of breath. According to the anecdotal reports from the health care workers, it has been suggested that the virus could reach the brain and can cause anosmia, hyposmia, hypogeusia, and hypopsia. Once the SARS-CoV-2 has entered the central nervous system (CNS), it can either exit in an inactive form in the tissues or may lead to neuroinflammation. Here, we aim to discuss the chronic infection of the olfactory bulb region of the brain by SARS-CoV-2 and how this could affect the nearby residing neurons in the host. We further review the probable cellular mechanism and activation of the microglia 1 phenotype possibly leading to various neurodegenerative disorders. In conclusion, SARS-CoV-2 might probably infect the olfactory bulb neuron enervating the nasal epithelium accessing the CNS and might cause neurodegenerative diseases in the future.

References

Aug 5, 2004·Annals of Neurology·Mirthe M PonsenHenk W Berendse
Jan 23, 2009·Prion·Roma N Rambaran, Louise C Serpell
Jul 14, 2009·Journal of Clinical Psychopharmacology·Latha Velayudhan, Simon Lovestone
Aug 19, 2009·Annals of the New York Academy of Sciences·Hong WangLiquan Huang
Apr 22, 2011·Nature Reviews. Immunology·Dorian B McGavern, Silvia S Kang
Apr 23, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Marie-Francoise DoursoutRoger J Bick
Jun 18, 2016·Mediators of Inflammation·Tobias DahmTobias Tenenbaum
Oct 17, 2017·Journal of Veterinary Science·Yoojin SeoKyung-Sun Kang
Sep 27, 2019·Acta Neuropsychiatrica·Anila VenugopalBalachandar Vellingiri
Apr 2, 2020·Neurology·Avindra Nath
Apr 8, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jerome R LechienSven Saussez
Apr 12, 2020·The Science of the Total Environment·Balachandar VellingiriMohana Devi Subramaniam
Apr 17, 2020·Journal of the Neurological Sciences·Ali A Asadi-Pooya, Leila Simani
Apr 19, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Annalisa MarinosciAlexandra Calmy
Apr 19, 2020·The Lancet Infectious Diseases·Michael S XydakisClaire Hopkins
Apr 22, 2020·Journal of Medical Virology·Alberto Paniz-MondolfiMary Fowkes
Apr 23, 2020·ACS Chemical Neuroscience·Gaurav DasSurajit Ghosh
Apr 25, 2020·Curēus·Asia FilatovPatricio S Espinosa
May 1, 2020·Brain, Behavior, and Immunity·Giuseppe De Santis
May 2, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Fadi Al SaieghM Reid Gooch
May 3, 2020·Neurology·Marc DinkinDana Leifer
May 4, 2020·The Science of the Total Environment·Vellingiri BalachandarSsang-Goo Cho
May 16, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Imran Ahmad, Farooq Azam Rathore
May 19, 2020·Clinical Neurology and Neurosurgery·V MontalvanK Rivas
May 21, 2020·JAMA : the Journal of the American Medical Association·Katherine Lisa Whitcroft, Thomas Hummel
May 27, 2020·Journal of Neurology·Georgios TsivgoulisSotirios Tsiodras
Jun 9, 2020·Annals of Neurology·Igor J Koralnik, Kenneth L Tyler
Jun 23, 2020·Journal of the Neurological Sciences·Pranusha PinnaIvan Da Silva
Jun 24, 2020·Frontiers in Public Health·Patricia Gómez-IglesiasJorge Matías-Guiu

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Citations

Dec 18, 2020·International Journal of Environmental Research and Public Health·Carlos E Galván-TejadaIrma E Gonzalez-Curiel
Mar 20, 2021·Frontiers in Cellular Neuroscience·Elisa Gonçalves de AndradeMarie-Ève Tremblay
May 11, 2021·Frontiers in Neurology·Austin Perlmutter
May 15, 2021·Journal of Chemical Neuroanatomy·Harini Sri RethinavelMahesh Kandasamy
Jul 9, 2021·Environmental Research·Iyer MahalaxmiBalachandar Vellingiri
Jul 30, 2021·Journal of Chemical Neuroanatomy·Sara Mohamed Naguib Abdel Hafez
Aug 17, 2021·Journal of Biological Rhythms·Rachel S HerzSara B Noya

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