COVID-19 and the gastrointestinal tract: what do we already know?

Einstein
Joana Ferro Machado de Almeida, Ethel Zimberg Chehter

Abstract

The new coronavirus disease pandemic is defining 2020, with almost 17.5 million infected individuals and 700 thousand deaths up to beginning of August. It is caused by SARS-CoV-2 and the transmission is through the respiratory tract. Those infected may be asymptomatic, present typical symptoms (fever, dry cough and dyspnea), gastrointestinal symptoms (diarrhea, nausea, vomiting and abdominal pain) and viral RNA in stools. The objective of this work was to review the literature related to the prevalence of gastrointestinal symptoms, and to check the possibility of fecal-oral transmission. We searched PubMed® database on COVID-19 and gastrointestinal tract and selected articles using the PRISMA method. We eliminated articles based on titles and abstracts, small number of patients and the mechanism of infection, leaving 14 studies. Comorbidities and laboratory alterations (elevation of hepatic aminotransferases and bilirubin) were related to worsening of the disease. The prevalence of gastrointestinal symptoms ranged from 6.8% to 61.3%, including diarrhea (8.14% to 33.7%), nausea/vomiting (1.53% to 26.4%), anorexia (12.1% to 40.0%) and abdominal pain (0% to 14.5%). The presence of viral RNA in stools was rarely tested, but positiv...Continue Reading

References

Jul 8, 2008·Immunology Letters·Andrew M Platt, Allan McI Mowat
Mar 20, 2018·Advances in Virus Research·Victor M CormanChristian Drosten
Mar 7, 2020·Gastroenterology·Fei XiaoHong Shan
Mar 13, 2020·Journal of Medical Virology·Long-Quan LiYuping Wang
Mar 23, 2020·Gastroenterology·Zili ZhouXiaogang Shu
Apr 10, 2020·The European Respiratory Journal·Janice M LeungDon D Sin
Apr 13, 2020·Diabetes Research and Clinical Practice·Akhtar HussainNayla Cristina do Vale Moreira
Apr 15, 2020·Nature Medicine·Kristian G AndersenRobert F Garry
Apr 19, 2020·The Lancet. Gastroenterology & Hepatology·Yunle WanPing Lan
Jun 20, 2020·JAMA : the Journal of the American Medical Association·Emil L FosbølLars Køber

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Citations

Jul 31, 2021·World Journal of Gastroenterology : WJG·Paulina Delgado-GonzalezElsa N Garza-Treviño

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Methods Mentioned

BETA
PCR

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