COVID-19 and the Gut Microbiome: More than a Gut Feeling

MSystems
Daniel van der Lelie, Safiyh Taghavi

Abstract

Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus disease 2019 (COVID-19). Understanding the "gut-lung axes," where gut microbiome composition influences the lung's susceptibility to viral infections and viral infections of the lung alter gut microbiome composition toward proinflammatory functional dysbiosis, will be critical in addressing COVID-19, including disease progression, the importance of preexisting conditions, and the risk for developing complications. These insights may further help to develop better intervention strategies for COVID-19 and other diseases caused by respiratory viruses.

References

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Apr 25, 2020·MedRxiv : the Preprint Server for Health Sciences·W. GouJu-Sheng Zheng

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Citations

Oct 4, 2020·Microorganisms·Anastasia MantziariJeadran Nevardo Malagón-Rojas
Dec 3, 2020·MSystems·UNKNOWN Microbiome Centers Consortium COVID Committee
Jan 30, 2021·World Journal of Clinical Cases·Arunkumar KrishnanTinsay A Woreta
Mar 9, 2021·Frontiers in Medicine·Christian A DevauxDidier Raoult
Mar 18, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jayani C KariyawasamSuranjith L Seneviratne
Jul 27, 2021·Nutrition and Cancer·Gang TangZhengqiang Wei

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Methods Mentioned

BETA
PCR

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