COVID-19 and the Heart and Vasculature: Novel Approaches to Reduce Virus-Induced Inflammation in Patients With Cardiovascular Disease.

Arteriosclerosis, Thrombosis, and Vascular Biology
Bernard S KadoshStuart D Katz

Abstract

The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented challenge and opportunity for translational investigators to rapidly develop safe and effective therapeutic interventions. Greater risk of severe disease in COVID-19 patients with comorbid diabetes mellitus, obesity, and heart disease may be attributable to synergistic activation of vascular inflammation pathways associated with both COVID-19 and cardiometabolic disease. This mechanistic link provides a scientific framework for translational studies of drugs developed for treatment of cardiometabolic disease as novel therapeutic interventions to mitigate inflammation and improve outcomes in patients with COVID-19.

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Citations

Feb 23, 2021·Platelets·Silvio Antoniak, Nigel Mackman
Mar 26, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Shigeo GodoHiroaki Shimokawa
Mar 30, 2021·Frontiers in Endocrinology·Sravya JannapureddyRavichandran Ramasamy
May 1, 2021·International Journal of Molecular Sciences·Yin LiangKen Takahashi
May 22, 2021·Computers in Biology and Medicine·Deepyaman Das, Soumita Podder
Aug 10, 2021·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Antonios KousaxidisAthina Geronikaki

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Methods Mentioned

BETA
GTPases

Clinical Trials Mentioned

NCT04083339
NCT04365699
NCT04350593
NCT04341935
NCT04371978
NCT04322682
NCT04362111
NCT04341584
NCT04365153
NCT04333407

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