Abstract
To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 coronavirus. Our literature and clinical trial survey showed that the whole virus, as well as the spike (S) protein, nucleocapsid (N) protein, and membrane protein, have been tested for vaccine development against SARS and MERS. We further used the Vaxign reverse vaccinology tool and the newly developed Vaxign-ML machine learning tool to predict COVID-19 vaccine candidates. The N protein was found to be conserved in the more pathogenic strains (SARS/MERS/COVID-19), but not in the other human coronaviruses that mostly cause mild symptoms. By investigating the entire proteome of SARS-CoV-2, six proteins, including the S protein and five non-structural proteins (nsp3, 3CL-pro, and nsp8-10) were predicted to be adhesins, which are crucial to the viral adhering and host invasion. The S, nsp3, and nsp8 proteins were also predicted by Vaxign-ML to induce high protective antigenicity. Besides the commonly used S protein, the nsp3 protein has not been tested in any coronavirus vaccine studies and was selected for further investigation. The nsp3 was found to be more co...Continue Reading
Citations
Aug 3, 2020·Journal of Medical Systems·Agam BansalAllan Klein
Sep 19, 2020·Journal of Medical Internet Research·Jiayang Chen, Kay Choong See
Mar 29, 2020·Physiological Genomics·Ahmad AlimadadiXi Cheng
Sep 7, 2020·Journal of Nanobiotechnology·Estefânia V R CamposLeonardo Fernandes Fraceto
Jun 14, 2020·Scientific Data·Yongqun HeBarry Smith
Jul 25, 2020·Human Vaccines & Immunotherapeutics·Wangxue Chen
Oct 29, 2020·PloS One·Jordan J BirdDiego R Faria
Dec 3, 2020·Respiratory Research·Meghana RastogiSunit K Singh
Dec 23, 2020·Life Sciences·Marcelle Moura SilveiraMarcelo Mendonça
Dec 3, 2020·SN Computer Science·L J MuhammadI A Mohammed
Dec 15, 2020·Expert Review of Anti-infective Therapy·Zahra PayandehMasoomeh Dadkhah
Dec 17, 2020·JMIR Medical Informatics·Hafsa Bareen SyedaFeliciano Yu
Jan 19, 2021·Journal of Oral and Maxillofacial Pathology : JOMFP·T Smitha, Anela Thomas
Feb 23, 2021·Emergent Materials·Anjani Devi ChintaguntaSampath Kumar N S
Mar 19, 2021·Frontiers in Artificial Intelligence·Arash Keshavarzi ArshadiJiann Shiun Yuan
Apr 20, 2021·Informatics in Medicine Unlocked·Mohammad Sadeq MottaqiHedieh Sajedi
Jul 3, 2021·Vaccines·Andrés Felipe CuspocaJuvenal Yosa Reyes
Jul 20, 2021·Journal of Biomedical Semantics·Shane BabcockBarry Smith
Jul 4, 2020·Journal of Biomolecular Structure & Dynamics·Richa BhatnagerAmita S Dang
Sep 5, 2021·Journal of Molecular Modeling·T PooventhiranRenjith Thomas
Sep 4, 2021·Scientific Reports·Kamal RawalMaria Elena Bottazzi