[COVID-19: Critical appraisal of the evidence].

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
Paz González Rodríguezen representación del Grupo de Trabajo de Pediatría Basada en la Evidencia de la AEP y AEPap

Abstract

We present the summary of a critical appraisal document of the available evidence on COVID-19, developed with a clinical practice guide format following GRADE methodology. The document tries to provide answers to a series of structured clinical questions, with an explicit definition of the population, intervention/exposure, comparison and outcome, and a rating of the clinical relevance of the outcome measures. We conducted a systematic review of the literature to answer the questions, grouped into six chapters: epidemiology, clinical practice, diagnosis, treatment, prevention, and vaccination. We assessed the risk of bias of the selected studies with standard instruments (RoB-2, ROBINS-I, QUADAS and Newcastle-Ottawa). We constructed evidence tables and, when necessary and possible, meta-analysis of the of the most relevant outcome measures. We followed the GRADE system to synthesize the evidence, assessing its quality, and, when appropriate, giving recommendations, rated according to the quality of the evidence, the values and preferences, the balance between benefits, risks and costs, equity and feasibility.

References

Jan 30, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Victor M CormanChristian Drosten
Apr 17, 2020·Nature Medicine·Xi HeGabriel M Leung
Apr 23, 2020·Pediatrics·Marco DeninaSilvia Garazzino
Jun 5, 2020·Lancet·Derek K ChuUNKNOWN COVID-19 Systematic Urgent Review Group Effort (SURGE) study authors
Jun 13, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·K F WalkerJ G Thornton
Jun 20, 2020·Pediatric Radiology·Susan C ShelmerdineUNKNOWN Collaborators of the European Society of Paediatric Radiology Cardiothoracic Imaging Taskforce
Jul 16, 2020·Pediatrics·Stefania BellinoUNKNOWN COVID-19 Working Group
Aug 1, 2020·BMJ : British Medical Journal·Reed Ac SiemieniukRomina Brignardello-Petersen
Aug 3, 2020·American Journal of Obstetrics and Gynecology·Alexander M KotlyarReshef Tal
Aug 4, 2020·JAMA : the Journal of the American Medical Association·Katherine A AugerJoanna E Thomson
Aug 14, 2020·MMWR. Morbidity and Mortality Weekly Report·Shana Godfred-CatoUNKNOWN California MIS-C Response Team
Sep 3, 2020·JAMA : the Journal of the American Medical Association·UNKNOWN WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working GroupJohn C Marshall
Sep 11, 2020·Journal of Tropical Pediatrics·Prateek Kumar PandaLesa Dawman
Sep 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly E HansonReem A Mustafa
Oct 17, 2020·Nature Communications·Roberto RaschettiDaniele De Luca
Nov 26, 2020·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·James A KingFinlay A McAlister
Nov 28, 2020·Critical Care : the Official Journal of the Critical Care Forum·Alberto García-SalidoUNKNOWN Spanish Pediatric Intensive Care Society working group on SARS-CoV-2 infection
Dec 15, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Peipei HuDingmei Zhang
Jan 30, 2021·JAMA Network Open·Monita KarmakarRenuka Tipirneni
Feb 5, 2021·The Pediatric Infectious Disease Journal·Kelly GraffLisa Abuogi
Feb 25, 2021·The New England Journal of Medicine·Noa DaganRan D Balicer
May 21, 2021·The Cochrane Database of Systematic Reviews·Vanessa PiechottaNicole Skoetz

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