COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review

Clinics and Practice
Attilio CavezziSalvatore Corrao

Abstract

Coronavirus disease-19 (COVID-19) has been regarded as an infective-inflammatory disease, which affects mainly lungs. More recently, a multi-organ involvement has been highlighted, with different pathways of injury. A hemoglobinopathy, hypoxia and cell iron overload might have a possible additional role. Scientific literature has pointed out two potential pathophysiological mechanisms: i) severe acute respiratory syndrome-coronavirus-2 (SARS-CoV- 2) interaction with hemoglobin molecule, through CD147, CD26 and other receptors located on erythrocyte and/or blood cell precursors; ii) hepcidin-mimetic action of a viral spike protein, inducing ferroportin blockage. In this translational medicinebased narrative review, the following pathologic metabolic pathways, deriving from hemoglobin denaturation and iron metabolism dysregulation, are highlighted: i) decrease of functioning hemoglobin quote; ii) iron overload in cell/tissue (hyperferritinemia); iii) release of free toxic circulating heme; iv) hypoxemia and systemic hypoxia; v) reduction of nitric oxide; vi) coagulation activation; vii) ferroptosis with oxidative stress and lipoperoxidation; viii) mitochondrial degeneration and apoptosis. A few clinical syndromes may follow, such...Continue Reading

References

Aug 1, 1987·Journal of Applied Physiology·P BärtschW P Straub
Jun 29, 2000·The Journal of Biological Chemistry·M M VanDuijnJ Van Der Zee
Oct 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sagan KCDavid W Golde
Dec 18, 2009·Haematologica·Pathrapol LithanatudomDuncan R Smith
Sep 20, 2011·Current Opinion in Biotechnology·Maria Daglia
Feb 7, 2012·Biochimica Et Biophysica Acta·Tomas Ganz, Elizabeta Nemeth
Feb 9, 2012·Seminars in Thrombosis and Hemostasis·Giovanni TargherGiuseppe Lippi
Mar 27, 2012·The Journal of Clinical Investigation·Mark T GladwinDaniel B Kim-Shapiro
Oct 24, 2012·Biochimica Et Biophysica Acta·Devin MorrisVishwanath Venketaraman
Apr 19, 2013·Current Opinion in Hematology·Heather O'LearyHal E Broxmeyer
Jun 1, 2013·Current Neurovascular Research·Boguslaw Lipinski, Etheresia Pretorius
Jun 19, 2015·Clinical Microbiology Reviews·Laura Cooling
Feb 22, 2017·General Physiology and Biophysics·Sabina GaliniakIzabela Sadowska-Bartosz
Jun 18, 2017·Current Medicinal Chemistry·Valeria PittalaValeria Sorrenti
Jun 29, 2017·Nutrients·Mustapha Umar ImamFudi Wang
Nov 14, 2017·Biochemical and Biophysical Research Communications·Jamie L KuckLorraine B Ware
Dec 17, 2017·Mitochondrion·Seong-Jun KimAleem Siddiqui
Jun 1, 2018·Annual Review of Nutrition·Marianne Wessling-Resnick
Aug 30, 2018·Scientific Reports·Latha RamakrishnanGregory J Quinlan
Oct 1, 2018·Free Radical Biology & Medicine·Tal Hirschhorn, Brent R Stockwell
Jan 6, 2019·Pharmaceuticals·Joana NevesMartina U Muckenthaler
Oct 6, 2019·Frontiers in Bioscience (Landmark Edition)·Sophie Marion Schmidt
Nov 30, 2019·Pharmaceuticals·Zachary J HawulaGautam Rishi
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Mar 15, 2020·The Journal of Infection·Ibrahim M IbrahimAbdo A Elfiky
Mar 29, 2020·Life Sciences·Rui ZhangRussel J Reiter
Apr 3, 2020·Journal of Thrombosis and Haemostasis : JTH·Jecko Thachil
Apr 18, 2020·Critical Care : the Official Journal of the Critical Care Forum·Luciano GattinoniSandra Rossi
Apr 21, 2020·Stem Cell Reviews and Reports·Henning Ulrich, Micheli M Pillat
Apr 21, 2020·American Journal of Hematology·Irene MottaGian L Forni
Apr 23, 2020·Current Clinical Microbiology Reports·Wei LiuSijin Liu
Apr 23, 2020·International Journal of Molecular Medicine·Anatoly V SkalnyAlexey A Tinkov
Apr 24, 2020·Lancet·Zsuzsanna VargaHolger Moch
Apr 25, 2020·International Journal of Dermatology·Nerea LandaTeresa Aguirre
Apr 27, 2020·Diabetes/metabolism Research and Reviews·Rocky Strollo, Paolo Pozzilli
May 23, 2020·Current Problems in Cardiology·Sevim ZaimAmer Harky
Jul 14, 2020·JACC. Cardiovascular Imaging·Yuman LiMingxing Xie

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Citations

Sep 2, 2020·European Journal of Clinical Pharmacology·Anis Abobaker
Jul 15, 2020·Journal of Endocrinological Investigation·A SansoneE A Jannini
Aug 23, 2020·Antioxidants·Paolo Bellavite, Alberto Donzelli
Sep 10, 2020·Clinical Kidney Journal·Lucia Del Vecchio, Francesco Locatelli
Sep 18, 2020·The American Journal of Tropical Medicine and Hygiene·Aila SarkeshHossein Bannazadeh Baghi
Nov 11, 2020·Journal of Food Biochemistry·Carmen Lammi, Anna Arnoldi
Nov 19, 2020·Bioscience Reports·Animesh Alexander RahaRuma Raha-Chowdhury
Nov 27, 2020·Journal of Medical Virology·Timotius Ivan Hariyanto, Andree Kurniawan
Dec 3, 2020·Medical Hypotheses·Gargi S SarodeShankargouda Patil
Dec 15, 2020·Medical Hypotheses·Elise LuponLaurent A Lantieri
Oct 17, 2020·Peptides·Patricia Ribeiro de CarvalhoPatricia Dias Fernandes
Oct 7, 2020·Medical Hypotheses·Little Flower AugustineBharati Kulkarni
Dec 1, 2020·Respiratory Medicine·Alpana Kumar GuptaRavi Mehrotra
Feb 9, 2021·Reviews in the Neurosciences·Priyanka NaguVineet Mehta
Nov 18, 2020·International Journal of Environmental Research and Public Health·Agnieszka Neumann-PodczaskaKatarzyna Wieczorowska-Tobis
Nov 20, 2020·International Journal of Molecular Sciences·Elettra BarberisMarcello Manfredi
Jan 18, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hosam M HabibWissam H Ibrahim
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bwalya A WitikaRoderick B Walker
Jan 26, 2021·Frontiers in Veterinary Science·Mahmoud AlagawanyMohamed E Abd El-Hack
Dec 11, 2020·Journal of Immunology Research·Fernanda Dos AnjosMargarete Dulce Bagatini
Dec 30, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adonis SferaJose Campo Maldonado
Nov 15, 2020·Journal of Clinical Medicine·Keiichi MitsuyamaSatoshi Matsumoto
Mar 15, 2021·Mayo Clinic Proceedings·Mark A CappelDavid A Wetter
Mar 26, 2021·Frontiers in Molecular Biosciences·Karthik VivekanandhanMuthupandian Saravanan
Dec 10, 2020·Cytokine & Growth Factor Reviews·Moiz Bakhiet, Sebastien Taurin
Nov 7, 2020·International Reviews of Immunology·Vijay Kumar
Apr 13, 2021·Expert Review of Anti-infective Therapy·Masoumeh Sadat Mousavi MalekiHamid Madanchi
May 1, 2021·Cells·Fien DemeulemeesterFemke van Doesburg
Apr 21, 2021·Archivos de bronconeumología·Sergi Pascual-GuàrdiaJoaquim Gea

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Methods Mentioned

BETA
rheology

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