COVID-19 in a Cohort of Patients with Congenital Myasthenic Syndrome.

Journal of Neuromuscular Diseases
Setareh AlabafJacqueline Palace

Abstract

Congenital Myasthenic Syndromes (CMS) are a rare group of genetic disorders of neuromuscular transmission. Some subtypes of CMS can be associated with respiratory and bulbar weakness and these patients may therefore be at high risk of developing a severe disease from COVID-19. We screened 73 patients with genetically confirmed CMS who were attending the UK national referral centre for evidence of previous Severe Acute Respiratory Syndrome Corona Virus 2 infection and their clinical outcome. Of 73 patients, seven had history of confirmed COVID-19. None of the infected patients developed a severe disease, and there were no signals that CMS alone carries a high risk of severe disease from COVID-19.

References

Aug 19, 2008·Journal of Neuroimmunology·Jackie Palace, David Beeson
Oct 12, 2014·Journal of Neurology·Pedro M Rodríguez CruzDavid Beeson
Jan 24, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Silvia Bonanno, Lorenzo Maggi

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