Covid-19 in a patient with multiple sclerosis treated with natalizumab: May the blockade of integrins have a protective role?

Multiple Sclerosis and Related Disorders
Clara AguirreJose Vivancos

Abstract

The disease caused by the new coronavirus SARS-CoV-2 (COVID-19) is currently spread worldwide . Recent data supports SARS-CoV-2 may use integrins to enter human cells. Therefore, anti-integrins therapies might be an alternative against the infection . Natalizumab, approved for Multiple Sclerosis (MS) treatment, acts blocking α4-integrin. We report a MS patient treated with natalizumab who develops COVID-19, with excellent recovery and repeated negative results in 5 consecutive microbiological studies. We postulate this may be due to the blockade of integrins induced by natalizumab.

References

Sep 1, 2015·Archives of Virology·Hosni A M HusseinShaw M Akula
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Apr 5, 2020·Journal of Medical Virology·Ilaria TresoldiAndrea Modesti
May 4, 2020·Lancet Neurology·Maria Pia Sormani, UNKNOWN Italian Study Group on COVID-19 infection in multiple sclerosis
May 11, 2020·Multiple Sclerosis and Related Disorders·Giovanna Borriello, Antonio Ianniello

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Citations

Sep 1, 2020·Journal of Neurology·Vittorio ManteroChristian Cordano
Oct 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Tobias ZrzavyThomas Berger
Jan 5, 2021·Journal of Immunoassay & Immunochemistry·Mai M Anwar
Oct 27, 2020·JACC. Basic to Translational Science·Brandon J BeddingfieldGregory J Bix
Jan 5, 2021·Current Opinion in Psychiatry·Lindsay S McAlpineSerena Spudich
Feb 13, 2021·Multiple Sclerosis and Related Disorders·Maryam Sharifian-DorchePaul Steven Giacomini
Mar 1, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Juan LiJing Wang
May 25, 2021·Acta Neurologica Scandinavica·Anne-Marie LandtblomEllen Iacobaeus
Aug 4, 2021·Neurology. Neuroimmunology and Neuroinflammation·Kelli M MoneyJacob A Sloane
Aug 15, 2021·Life Sciences·Narayanappa AmrutaGregory Bix
Dec 7, 2021·Frontiers in Cellular and Infection Microbiology·Christopher A BeaudoinAntony P Jackson

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Methods Mentioned

BETA
PCR

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