COVID-19 in a severe eosinophilic asthmatic receiving benralizumab - a case study.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Andreas RennerWolfgang Pohl

Abstract

Only little is known about COVID-19 in patients with asthma. There is no data on COVID-19 in patients with severe asthma or patients with asthma who are treated with monoclonal antibodies. Here, we present the case of a severe eosinophilic asthmatic in whom benralizumab treatment, an anti-IL-5R monoclonal antibody, was initiated 2 years ago. Prior to benralizumab treatment, every viral infection had resulted in a prolonged course of oral corticosteroids (OCS). Since initiation of benralizumab, the patient has had good asthma control. Mid-March 2020, the patient developed high fever. A SARS-CoV-2-PCR (nasopharyngeal swab) was positive. The patient's symptoms subsided after few days. No OCS was needed. The asthma control questionnaire 6-item scale worsened moderately in the week of the infection and returned to normal levels thereafter. The asthma control test, measuring longer term asthma control, showed no decline. The course of COVID-19 was very mild in this particular patient with severe eosinophilic asthma. So far, there is no evidence that would suggest a more severe course of COVID-19 in patients with asthma. It is worth noting, that prior to the initiation of benralizumab this patient had multiple exacerbations per year t...Continue Reading

Citations

Dec 2, 2020·ERJ Open Research·Andreas RennerWolfgang Pohl
Mar 18, 2021·Seminars in Immunopathology·Helene F Rosenberg, Paul S Foster
Mar 27, 2021·Frontiers in Pharmacology·Daniele Pala, Marco Pistis
Apr 4, 2021·Biomedicines·Francesco MenzellaNicola Cosimo Facciolongo
May 4, 2021·Global Health & Medicine·Masayuki HojoHaruhito Sugiyama
Jun 1, 2021·Pulmonology·João Gaspar-MarquesCláudia Chaves Loureiro
Jul 3, 2021·International Journal of Molecular Sciences·José M Rodrigo-MuñozVictoria Del Pozo
Jul 16, 2021·Asthma Research and Practice·Carlo LombardiMarcello Cottini
Sep 22, 2021·Current Opinion in Allergy and Clinical Immunology·Amélia RibeiroMário Morais-Almeida
Jan 28, 2022·European Respiratory Review : an Official Journal of the European Respiratory Society·David J JacksonFlorence Roufosse

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