COVID-19 in lung transplant recipients: A case series from Milan, Italy

Transplant Infectious Disease : an Official Journal of the Transplantation Society
Letizia Corinna MorlacchiFrancesco Blasi

Abstract

Limited data are currently available regarding the course of COVID-19 in lung and solid organ transplant recipients. We hereby present four cases of SARS-CoV-2 pneumonia in lung transplant recipients from our center, set in Milan, Italy. We reduced immunosuppressive regimen in all these patients, typically holding the antiproliferative agent and augmenting steroids; everybody received hydroxychloroquine, initial empiric antibiotic treatment with piperacillin/tazobactam, and high-dose low molecular weight heparin. Clinical course seemed favorable in three of our patients, but one of them deteriorated after 10 days of hospitalization, probably due to an acute form of graft dysfunction triggered both by COVID-19 and a nosocomial bacterial infection, and eventually died. Although short-term prognosis could be considered benign in the majority of our patients, we should carefully monitor these individuals in order to detect early sign of clinical deterioration and graft dysfunction in the next few months.

Associated Clinical Trials

Nov 11, 2021·Letizia Morlacchi

References

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Citations

Oct 16, 2020·Nature Reviews. Microbiology·Olivier VandenbergZisis Kozlakidis
Mar 1, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Arta KarruliEmanuele Durante-Mangoni
Jun 3, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Sara H Al-HadidiNahla O Eltai
Jul 19, 2021·The Journal of Thoracic and Cardiovascular Surgery·Thomas Schweiger, Konrad Hoetzenecker
Jul 30, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sinan TurkkanErdal Yekeler
Aug 31, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Andrew M HallettErrol L Bush
Dec 18, 2021·Seminars in Respiratory and Critical Care Medicine·Anna StainerStefano Aliberti

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