COVID-19 in rheumatic disease patients on immunosuppressive agents

Seminars in Arthritis and Rheumatism
Saika SharmeenQingping Yao

Abstract

To analyze clinical characteristics and outcome of COVID-19 patients with underlying rheumatic diseases (RD) on immunosuppressive agents. A case series of COVID-19 patients with RD on disease modifying anti-rheumatic drugs (DMARDs) were studied by a retrospective chart review. A literature search identified 9 similar studies of single cases and case series, which were also included. There were 4 COVID-19 inpatients with RD from our hospital, and the mean age was 57 ± 21 years. Two patients had a mild infection, and 2 developed severe COVID-19 related respiratory complications, including 1 patient on secukinumab requiring mechanical ventilation and 1 patient on rituximab developing viral pneumonia requiring supplemental oxygenation. All 4 patients had elevated acute phase reactants, 2 patients had mild COVID-19 with lymphopenia, and 2 patients had severe COVID-19 with normal lymphocyte counts, and high levels of IL-6. None of the patients exhibited an exacerbation of their underlying RD. In the literature, there were 9 studies of COVID-19 involving 197 cases of various inflammatory RD. Most patients were on DMARDs or biologics, of which TNFα inhibitors were most frequently used. Two tocilizumab users had a mild infection. Two pa...Continue Reading

Citations

Jul 28, 2020·Annals of the Rheumatic Diseases·Xiao-Huan ChenJames Cheng Chung Wei
Jan 4, 2021·Rheumatology International·Sakir AhmedOlena Zimba
Jan 30, 2021·Current Rheumatology Reports·Aikaterini Thanou, Amr H Sawalha
Dec 24, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Elena BeyzarovPatrick Caubel
Oct 15, 2020·Dermatologic Therapy·Amir Mohammad BeyzaeeMohamad Goldust
Sep 7, 2020·Journal of the American Academy of Dermatology·Joel M GelfandChristopher T Ritchlin
Sep 15, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sudarsan KrishnasamyArvind Bagga

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