COVID-19 in the Context of Inborn Errors of Immunity: a Case Series of 31 Patients from Mexico.

Journal of Clinical Immunology
Lina M Castano-JaramilloSaul O Lugo Reyes

Abstract

Patients with inborn errors of immunity (IEI) have a compromised or inappropriate immune response. Although they might be considered a high-risk group for severe SARS-CoV-2 infection, the reported impact of COVID-19 in these patients has been reassuring, while the differential susceptibility of distinct types of IEI remains unclear. We aimed to describe the findings and outcomes of our known patients with IEI who were diagnosed with COVID-19. In a retrospective study from March 2020 to February 2021, four centers in Mexico collected clinical, laboratory, and genetic data from pediatric and adult patients with known diagnoses of IEI who presented with COVID-19, based on compatible symptoms and positive SARS-CoV-2 testing or known household exposure. We report 31 patients with known IEI from Mexico who presented with SARS-CoV-2 infection. Seventy-four percent were male, 52% were pediatric, and 81% survived. Their ages ranged from 5 months to 56 years, with a median of 17 years. Sixty-five percent had predominant antibody deficiencies, 48% were hospitalized, and 26% required ICU. Pediatric patients had a higher hospital admission rate than adults. Inpatient mortality was 40%, and ICU mortality rate was 63%. Forty-eight percent dev...Continue Reading

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Citations

Sep 8, 2021·The Journal of Allergy and Clinical Immunology·Ottavia M DelmonteAlexandra F Freeman
Nov 5, 2021·Current Opinion in Pediatrics·Giorgia BucciolIsabelle Meyts

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