COVID-19 infection in first trimester of pregnancy marked by a liver cytolysis in a woman previously treated by hydroxychloroquine for repeated implantation failure: a case report

BMC Infectious Diseases
F LamazouL Delaroche

Abstract

In December 2019, a new disease (COVID-19) caused by a novel coronavirus called SARS-CoV-2 emerged in China and spread to many other countries. There is only limited data about the clinical features of COVID-19 during pregnancy, especially in first trimester. We report a COVID-19 infection in a 35 years-old patient in first trimester of pregnancy and its consequent medical care. At 7 weeks of pregnancy, the patient, who did not have any pregestational comorbidities, complained of intense nausea and asthenia. An important liver cytolysis was discovered with biological perturbations of transaminases levels. No respiratory symptoms were recorded. Classical viral aetiologies and drug-related toxicity were discarded. Because of the aggravation of the symptoms and the occurrence of the breathlessness, the patient was tested for the COVID-19 in a nasopharyngeal swab. The RTq-PCR assay indicated the presence of SARS-CoV-2 RNA. In the absence of severe symptoms, the patient was monitored at home according to the French government guidelines. After a few days, the symptoms resolved without any complications. The pregnancy is still ongoing without any visible sequelae on the foetus so far. This first case illustrated the difficulty of COV...Continue Reading

References

Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 28, 2020·American Journal of Obstetrics and Gynecology·Sonja A RasmussenDenise J Jamieson
Mar 8, 2020·The Lancet. Gastroenterology & Hepatology·Chao ZhangFu-Sheng Wang
Mar 11, 2020·Translational Pediatrics·Huaping ZhuWenhao Zhou
Mar 24, 2020·The Lancet. Gastroenterology & Hepatology·Mansoor N BangashDhruv Parekh
Mar 25, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shihua LuoHaibo Xu
Mar 28, 2020·Journal of Gastroenterology and Hepatology·Sunny H WongJoseph Jy Sung
Mar 31, 2020·Alimentary Pharmacology & Therapeutics·Yuan TianYan He
Apr 3, 2020·Fetal and Pediatric Pathology·Mojgan Karimi-ZarchiReza Bahrami
Apr 3, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Hansheng XieHuichang Zhuo
Apr 3, 2020·The Lancet Infectious Diseases·Robert VerityNeil M Ferguson
Apr 3, 2020·Journal of Reproductive Immunology·Golshan SheikhansariMehdi Yousefi
Apr 8, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Mehreen Zaigham, Ola Andersson
Apr 11, 2020·Journal of Clinical and Translational Hepatology·Gong FengMing-Hua Zheng
Apr 12, 2020·Clinical Rheumatology·Durga Prasanna MisraOlena Zimba
Apr 15, 2020·Frontiers of Medicine·Wei LiuZhihui Rong
Apr 18, 2020·Journal of Thrombosis and Haemostasis : JTH·Hidesaku Asakura, Haruhiko Ogawa
Apr 18, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Pu YangDongchi Zhao
Apr 21, 2020·Journal of the American College of Cardiology·Behnood BikdeliUNKNOWN Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working
Apr 27, 2020·American Journal of Obstetrics and Gynecology·Jie YanHuixia Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.