COVID-19: molecular targets, drug repurposing and new avenues for drug discovery

Memórias do Instituto Oswaldo Cruz
Mario Roberto SengerFloriano Paes Silva-Junior

Abstract

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment.

References

Jul 18, 1983·The American Journal of Medicine·E W McChesney
Mar 21, 2003·Nature·Caitlin Smith
Nov 1, 2003·The Lancet Infectious Diseases·Andrea SavarinoRoberto Cauda
Aug 3, 2004·Nature Reviews. Drug Discovery·Ted T Ashburn, Karl B Thor
Apr 7, 2006·Expert Review of Anti-infective Therapy·Erik De Clercq
Nov 26, 2008·Chembiochem : a European Journal of Chemical Biology·Ka To Shum, Julian A Tanner
Dec 26, 2008·International Journal of Antimicrobial Agents·Erik De Clercq
Feb 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yu ChenDeyin Guo
Jul 14, 2009·PLoS Pathogens·Konstantin PervushinJaume Torres
Jan 1, 2010·Journal of Pharmacy & Bioallied Sciences·Himanshu GuptaR S Gaud
May 17, 2012·Viruses·Travis R Ruch, Carolyn E Machamer
May 17, 2012·Viruses·Taylor Heald-Sargent, Tom Gallagher
Sep 1, 2012·Biochemical Pharmacology·Young-Sam Keum, Yong-Joo Jeong
Sep 14, 2012·Biological & Pharmaceutical Bulletin·Ji-Young ParkYoung Bae Ryu
Oct 26, 2013·Nucleic Acids Research·Neil D RawlingsAlex Bateman
Nov 26, 2013·Nucleic Acids Research·Vincent LombardBernard Henrissat
Mar 7, 2014·Clinical Science·Clare A McKinneyStuart A Nicklin
Jun 17, 2014·Virus Research·Fernando AlmazánLuis Enjuanes
Jul 31, 2014·The Journal of Biological Chemistry·Mickaël BouvetXavier Morelli
Apr 22, 2015·HIV/AIDS : Research and Palliative Care·Zhengtong LvYong Wang
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
Dec 1, 2012·Emerging Microbes & Infections·Colin R Howard, Nicola F Fletcher
Jul 18, 2015·Current Opinion in Virology·Lisa M Gretebeck, Kanta Subbarao
Oct 9, 2015·Translational Neurodegeneration·Yong-Bo HuGang Wang
Feb 13, 2016·Nature Reviews. Drug Discovery·Alimuddin ZumlaKwok-Yung Yuen
Sep 1, 2016·Annual Review of Virology·Fang Li
Jan 24, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Ji-Young ParkWoo Song Lee

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Citations

Mar 2, 2021·Journal of Infection and Public Health·Marwan ElBagouryAmy Hutchinson
Apr 23, 2021·Memórias do Instituto Oswaldo Cruz·Alberto Fernando Oliveira JustoNancy Bellei
May 13, 2021·Drug Design, Development and Therapy·Osama A BadaryRajiv Tikamdas
May 18, 2021·Frontiers in Cellular and Infection Microbiology·Elisa B PrestesLeticia A M Carneiro
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marjorie C L C FreireGlaucius Oliva
Oct 9, 2021·Briefings in Bioinformatics·Qiaoming LiuGuohua Wang

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Methods Mentioned

BETA
electron microscopy
deubiquitination
in silico methods
X-ray
glycosylation

Clinical Trials Mentioned

NCT04421027
NCT04320277
NCT04321993
NCT04252664
NCT04257656
NCT04280705
NCT04276688
NCT04292899
NCT04343768

Software Mentioned

GROMACS
Autodock Vina
SUMMIT
Maestro

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