COVID-19: pathogenesis, genetic polymorphism, clinical features and laboratory findings

Turkish Journal of Medical Sciences
Recep ÖztürkAkif Ayaz

Abstract

COVID-19 caused by a novel agent SARS-CoV-2 progressed to a pandemic condition and resulted in a major public health concern worldwide, leading to social and economic issues at the same time. The pathogenesis of COVID-19 starts with the bonding of the virus to ACE2 receptors expressed in many tissues, and the triggered excessive immune response plays a critical role in the course of the disease. The cytokine storm that occurs upon excessive production of pro-inflammatory cytokines is considered responsible for the severe progression of the disease and the organ damage. However, the accurate pathophysiological mechanism of the disease, which progresses with various clinical presentations, is still substantially unknown. While various studies have been conducted on the effect of genetic polymorphism on the course and severity of the disease, the presence of a significant effect has not been proven yet. The clinical course of the disease is variable, with clinical representation ranging from 81% mild course to 14% severe course along with 5% critical course in patients. Asymptomatic course is considered to be higher than expected, although its frequency is not known exactly. Older adults and those with comor...Continue Reading

Citations

Jul 22, 2020·Archives of Toxicology·Mathieu Vinken
Aug 4, 2021·Environmental Science and Pollution Research International·Ozgur Akin OtoAydın Turkmen
Aug 13, 2021·Human Fertility : Journal of the British Fertility Society·Marziye Farsimadan, Mohammad Motamedifar

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