COVID-19 Sepsis and Microcirculation Dysfunction

Frontiers in Physiology
Antonio ColantuoniGregorio Caimi

Abstract

The spreading of Coronavirus (SARS-CoV-2) pandemic, known as COVID-19, has caused a great number of fatalities all around the World. Up to date (2020 May 6) in Italy we had more than 28,000 deaths, while there were more than 205.000 infected. The majority of patients affected by COVID-19 complained only slight symptoms: fatigue, myalgia or cough, but more than 15% of Chinese patients progressed into severe complications, with acute respiratory distress syndrome (ARDS), needing intensive treatment. We tried to summarize data reported in the last months from several Countries, highlighting that COVID-19 was characterized by cytokine storm (CS) and endothelial dysfunction in severely ill patients, where the progression of the disease was fast and fatal. Endothelial dysfunction was the fundamental mechanism triggering a pro-coagulant state, finally evolving into intravascular disseminated coagulation, causing embolization of several organs and consequent multiorgan failure (MOF). The Italian Society of Clinical Hemorheology and Microcirculation was aimed to highlight the role of microcirculatory dysfunction in the pathogenetic mechanisms of COVID-19 during the spreading of the biggest challenges to the World Health.

References

Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott A JeffersKathryn V Holmes
Nov 14, 2006·Journal of Thrombosis and Haemostasis : JTH·C H TohUNKNOWN SSC on Disseminated Intravascular Coagulation of the ISTH
Dec 7, 2007·Intensive Care Medicine·R Phillip DellingerJean-Louis Vincent
Feb 13, 2008·The Journal of Experimental Medicine·Emre E TurerAveril Ma
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC II Group of Investigators
Aug 25, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Alma RusM Luisa Del Moral
Jun 24, 2011·Science Translational Medicine·Neil M GoldenbergWarren L Lee
Nov 24, 2011·The Journal of Experimental Medicine·Wenzhong XiaoUNKNOWN Inflammation and Host Response to Injury Large-Scale Collaborative Research Program
Dec 3, 2013·Current Heart Failure Reports·Mohammed A R Chamsi-PashaW H Wilson Tang
Mar 7, 2014·Frontiers in Immunology·Berit Carow, Martin E Rottenberg
Mar 15, 2014·PloS One·Alvaro H BorgesUNKNOWN SILCAAT Scientific Committee
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Keizo Takao, Tsuyoshi Miyakawa
Dec 7, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·E LetsiouS M Dudek
May 4, 2017·Seminars in Immunopathology·Rudragouda Channappanavar, Stanley Perlman
May 31, 2017·Seminars in Immunopathology·Benjamin G ChoustermanGeorg F Weber
Feb 28, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Eduardo RamacciottiJawed Fareed
Jul 18, 2019·Viruses·Sophie J SmitherEmrys Kirkman
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 18, 2020·Frontiers in Cellular Neuroscience·Dominga LapiEttore Novellino
Feb 23, 2020·The Lancet. Respiratory Medicine·Zhe XuFu-Sheng Wang
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 3, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sufang TianShu-Yuan Xiao
Mar 12, 2020·JAMA : the Journal of the American Medical Association·Wenling WangWenjie Tan
Mar 14, 2020·Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·M L SunG H Su
Mar 17, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jing YangYongning Zhou
Mar 22, 2020·Journal of Clinical Pathology·Brian HanleyMichael Osborn
Mar 31, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Wen ZhangShuyang Zhang
Apr 9, 2020·Pharmacotherapy·Simin Dashti-Khavidaki, Hossein Khalili
Apr 9, 2020·The New England Journal of Medicine·Yan ZhangShuyang Zhang
Apr 11, 2020·American Journal of Clinical Pathology·Lisa M BartonSanjay Mukhopadhyay
Apr 15, 2020·Circulation·Pietro Enea LazzeriniPier Leopoldo Capecchi
Apr 20, 2020·Thrombosis Research·Robert EscherBernhard Lämmle
Apr 21, 2020·Journal of the American College of Cardiology·Behnood BikdeliUNKNOWN Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working
Apr 26, 2020·Brain, Behavior, and Immunity·Jiancheng ZhangKenji Hashimoto
Apr 28, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea MagroneEmilio Jirillo
Apr 30, 2020·Intensive Care Medicine·Daniel E LeismanMatthieu Legrand

❮ Previous
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Citations

Jan 20, 2021·American Journal of Physiology. Renal Physiology·Licy L Yanes CardozoDamian G Romero
Feb 14, 2021·Reviews in the Neurosciences·Shaghayegh Sadeghmousavi, Nima Rezaei
Dec 22, 2020·Frontiers in Physiology·Aleksei G Golubev
Mar 23, 2021·Frontiers in Cellular and Infection Microbiology·Guoxing TangZiyong Sun
Apr 11, 2021·The Journal of Pathology. Clinical Research·Jasmin D HaslbauerKatharina Glatz
Apr 13, 2021·Brain, Behavior, & Immunity Health·Francisco J Barrantes
Apr 30, 2021·Indian Journal of Ophthalmology·Mallika GoyalSridhar Annum
May 21, 2021·Frontiers in Physiology·Shah-Abas MuhamadAmilia Aminuddin
Jun 11, 2021·Virusdisease·Swaraj MohantyYasmin Ahmad
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Salleh Annas, Mohd Zamri-Saad
Aug 3, 2021·Frontiers in Pharmacology·Guyi WangYanjun Zhong
Jul 20, 2021·Biomedical Engineering Letters·Jaesung LimChun Gwon Park
Aug 28, 2021·Biomolecules·Naiara Naiana DejaniDamião Pergentino de Sousa
Aug 30, 2021·Biochemical and Biophysical Research Communications·Youichi SuzukiNaoki Yamamoto
Sep 21, 2021·Bulletin of Experimental Biology and Medicine·B I KuznikD S Parts
Oct 26, 2021·Hämostaseologie·Andrea Gawaz, Emmanuella Guenova

❮ Previous
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