COVID-19 symptoms and SARS-CoV-2 infection among people living with HIV in the US: the MACS/WIHS combined cohort study.

HIV Research & Clinical Practice
Gypsyamber D'SouzaAda A Adimora

Abstract

SARS-CoV-2 infection among People Living With HIV (PLWH) is not well-described. To study COVID-19 symptoms and SARS-CoV-2 PCR-based swab testing among participants of the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS). A telephone survey was collected April-June 30, 2020. Symptom and testing prevalence were explored. Multivariable logistic regression was used to examine the factors associated with SARS-CoV-2 positivity. The survey was completed by 3411 participants, including 2078 (61%) PLWH and 1333 HIV-seronegative (SN) participants from across the US. Thirteen percent (n = 441) were tested for SARS-CoV-2 infection (13.4% of PLWH vs 12.2% of SN). Among those tested, positivity was higher in PLWH than SN (11.2% vs 6.1%, p = 0.08). Reasons for not being tested included testing not being available (30% of participants) and not knowing where to get tested (16% of participants). Most symptoms reported since January 2020 were similar in PLWH and SN, including headache (23% vs. 24%), myalgias (19% vs 18%), shortness of breath (14% vs 13%), chills (12% vs 10%), fever (6% vs 6%) and loss of taste or smell (6% vs 7%). Among PLWH who tested positive for SARS-CoV-2 DNA, the most common symptoms were headach...Continue Reading

References

Apr 2, 2014·Annals of Internal Medicine·Wendy S PostLisa P Jacobson
Jun 3, 2014·BMC Pulmonary Medicine·Matthew R GingoAlison Morris
Apr 1, 2020·The New England Journal of Medicine·Pavan K BhatrajuCarmen Mikacenic
Apr 16, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Huipeng GeXiangcheng Xiao
May 8, 2020·MMWR. Morbidity and Mortality Weekly Report·Jeremy A W GoldBrendan R Jackson
May 15, 2020·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN New York City Department of Health and Mental Hygiene (DOHMH) COVID-19 Response Team
May 28, 2020·The New England Journal of Medicine·Eboni G Price-HaywoodLeonardo Seoane
Jun 4, 2020·Annals of Internal Medicine·Daniel P Oran, Eric J Topol
Jun 20, 2020·MMWR. Morbidity and Mortality Weekly Report·Erin K StokesKathleen E Fullerton
Jul 22, 2020·Journal of Medical Virology·Osman N Kanwugu, Parise Adadi

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Citations

Jul 30, 2021·Immunity, Inflammation and Disease·SeyedAhmad SeyedAlinaghiOmid Dadras
Jul 8, 2021·Journal of the American College of Clinical Pharmacy : JAACP·Maria SorberaKelly Wen

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Methods Mentioned

BETA
PCR

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