COVID-19 target: A specific target for novel coronavirus detection

Gene Reports
Reza Kamali KakhkiAlireza Neshani

Abstract

An ongoing outbreak of pneumonia associated with a novel coronavirus has been reported worldwide and become a global health problem; hence, the diagnosis and differentiation of this virus from other types of coronavirus is essential to control of the disease. To this end, the analysis of genomics data plays a vital role in introducing a stronger target and consequently provides better results in laboratory examinations. The modified comparative genomics approach helps us to find novel specific targets by comparing two or more sequences on the nucleotide collection database. We, for the first time, detected ORF8 gene as a potential target for the detection of the novel coronavirus. Unlike previous reported genes (RdRP, E and N genes), ORF8 is entirely specific to the novel coronavirus (COVID-19) and has no cross-reactivity with other kinds of coronavirus. Accordingly, ORF8 gene can be used as an additional confirmatory assay.

References

Jan 15, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Reza Kamali KakhkiMahsa Sayadi
Jan 30, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Victor M CormanChristian Drosten

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Citations

Dec 18, 2020·Frontiers in Physiology·Puneet Kaur RandhawaManish K Gupta
Jan 17, 2021·Trends in Microbiology·Rahul K SuryawanshiDeepak Shukla
Apr 30, 2021·PloS One·Huseyin TombulogluKhaled R Alkharsah
May 1, 2021·Bioengineering·Tina Shaffaf, Ebrahim Ghafar-Zadeh
Jul 7, 2021·Expert Review of Anti-infective Therapy·Mingkun DiaoRongsong Li
Sep 21, 2021·Journal, Genetic Engineering & Biotechnology·Syeda Tasnim Quayum, Saam Hasan
Sep 28, 2021·ACS Infectious Diseases·Hyunju OhAnubhav Tripathi

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Methods Mentioned

BETA
PCR

Software Mentioned

Primer
Basic Local Alignment Search Tool ( BLAST )
BLAST
Primer Premier

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