COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response

Frontiers in Molecular Biosciences
Sanchit SethSrilakshmi Srinivasan

Abstract

An acute respiratory disorder (COVID-19) that accelerated across the globe has been found to be caused by a novel strain of coronaviruses (SARS-CoV-2). The absence of a specific antiviral drug or vaccination has promoted the development of immediate therapeutic responses against SARS-CoV-2. As increased levels of plasma chemokines and, cytokines and an uncontrolled influx of inflammatory cells were observed in lethal cases, it was concluded that the severity of the infection corresponded with the imbalanced host immunity against the virus. Tracing back the knowledge acquired from SERS and MERS infections, clinical evidence suggested similar host immune reactions and host ACE2 receptor-derived invasion by SARS-CoV-2. Further studies revealed the integral role of proteases (TMPRSS2, cathepsins, plasmin, etc.) in viral entry and the immune system. This review aims to provide a brief review on the latest research progress in identifying the potential role of proteases in SARS-CoV-2 viral spread and infection and combines it with already known information on the role of different proteases in providing an immune response. It further proposes a multidisciplinary clinical approach to target proteases specifically, through a combinator...Continue Reading

References

Mar 29, 2003·Drugs·Risto S Cvetkovic, Karen L Goa
Nov 1, 2003·The Lancet Infectious Diseases·Andrea SavarinoRoberto Cauda
Dec 22, 2004·Current Topics in Microbiology and Immunology·S G Sawicki, D L Sawicki
Aug 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Graham SimmonsPaul Bates
May 13, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tracey BaasMichael G Katze
Sep 18, 2007·Advances in Immunology·Gunnar PejlerSara Wernersson
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
Jul 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magdalena HagnBernd Jahrsdörfer
Jun 12, 2010·Molecular Immunology·Kirstin M HeutinckAjda T Rowshani
Jun 12, 2012·Nature Reviews. Drug Discovery·Nabil G Seidah, Annik Prat
Mar 25, 2014·Annual Review of Immunology·Jiaxi Wu, Zhijian J Chen
Apr 29, 2014·Expert Review of Vaccines·Naru ZhangLanying Du
Dec 3, 2014·Virus Research·Jean Kaoru Millet, Gary R Whittaker
Mar 3, 2015·Neurosurgical Focus·Encouse B GoldenThomas C Chen
Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Mar 24, 2017·Scientific Reports·Sawsan S Al-AmriAnwar M Hashem
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Aug 11, 2019·The Journal of Biological Chemistry·Anabelle PerrierSandrine Belouzard
Sep 17, 2019·Advances in Virus Research·M Alejandra Tortorici, David Veesler
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 6, 2020·Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·H LiB Cao
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng

❮ Previous
Next ❯

Citations

Feb 6, 2021·Chinese Journal of Integrative Medicine·Mariappan RajanAwanish Kumar
Apr 10, 2021·Photodiagnosis and Photodynamic Therapy·Mohammed Ali DheyabHawraa Ali Khaleel
Jun 3, 2021·International Journal of Molecular Sciences·Michael C McKelveyClifford C Taggart
Aug 4, 2021·Biochimica Et Biophysica Acta. General Subjects·Ali NajmeddinFarid Dorkoosh
Oct 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Matthew MahoneyJames W Janetka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.