COVID-19 treatment: Much research and testing, but far, few magic bullets against SARS-CoV-2 coronavirus

European Journal of Medicinal Chemistry
Vladimir V Kouznetsov

Abstract

The new virus of the of β-Coronaviruses genus, SARS-CoV-2, is the causative agent of coronavirus disease-2019 (COVID-19) and is winning a proverbial chess match against all players simultaneous, including physicians, clinicians, pathologists, doctors, scientists, economists, athletes and politicians. The COVID-19 outbreak has seriously threatened public health, killing the most vulnerable persons and causing general panic. To stop this disease, effective remedies (i.e., drugs, vaccines, personal protection elements, etc.) are urgently required. Unfortunately, no registered specific therapies (including antiviral therapies, immune-modulating agents and vaccines) are currently available to treat coronavirus infections, highlighting an urgent need for therapeutics targeting SARS-CoV-2. In this work, fourteen existing small molecule drugs or/and experimental drugs selected by experts and examined from the point of view of bioavailability via the Lipinski-Veber rules and assessment of their physicochemical descriptors. The aim of this study is to discover selected pattern similarities and peculiar characteristics that could be useful for antiviral drug optimization, drug combination or new antiviral agent design.

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Citations

Jan 13, 2021·Ethics, Medicine, and Public Health·H M Silva
Jan 25, 2021·European Journal of Medicinal Chemistry· Shagufta, Irshad Ahmad
Jan 29, 2021·Journal of the Endocrine Society·Laura Ochoa-CallejeroAlfredo Martínez
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Jun 18, 2021·The Nurse Practitioner·Amita AvadhaniBimbola Akintade

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Molinspiration
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