COVID-19 Vaccines: Current Understanding on Immunogenicity, Safety, and Further Considerations.

Frontiers in Immunology
Qian HeZhenglun Liang


The world has entered the second wave of the COVID-19 pandemic, and its intensity is significantly higher than that of the first wave of early 2020. Many countries or regions have been forced to start the second round of lockdowns. To respond rapidly to this global pandemic, dozens of COVID-19 vaccine candidates have been developed and many are undergoing clinical testing. Evaluating and defining effective vaccine candidates for human use is crucial for prioritizing vaccination programs against COVID-19. In this review, we have summarized and analyzed the efficacy, immunogenicity and safety data from clinical reports on different COVID-19 vaccines. We discuss the various guidelines laid out for the development of vaccines and the importance of biological standards for comparing the performance of vaccines. Lastly, we highlight the key remaining challenges, possible strategies for addressing them and the expected improvements in the next generation of COVID-19 vaccines.


Oct 24, 2014·Annual Review of Medicine·Jerome H KimNelson L Michael
Apr 15, 2016·Therapeutic Delivery·Andreas M ReichmuthDaniel Blankschtein
Apr 23, 2016·Human Vaccines & Immunotherapeutics·Chao Zhang, Dongming Zhou
Feb 23, 2017·Cell·Justin M RichnerMichael S Diamond
May 2, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kapil BahlGiuseppe Ciaramella
Jan 17, 2019·Viruses·Zhiqi SongChuan Qin
Feb 26, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Giulietta MaruggiDong Yu
Jul 5, 2019·Expert Review of Vaccines·Jean-Louis Excler, Jerome H Kim
Jan 11, 2020·Nature Biotechnology
Apr 1, 2020·The New England Journal of Medicine·Nicole LurieJane Halton
Apr 8, 2020·Immunity·Fatima Amanat, Florian Krammer
Jun 5, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xiaoli WangQuanyi Wang
Jun 25, 2020·BioRxiv : the Preprint Server for Biology·Kizzmekia S CorbettBarney S Graham
Jun 26, 2020·Cell Host & Microbe·Jiandong HuoDavid I Stuart
Jun 27, 2020·BioRxiv : the Preprint Server for Biology·Lizhou ZhangHyeryun Choe
Jul 15, 2020·The New England Journal of Medicine·Lisa A JacksonUNKNOWN mRNA-1273 Study Group
Jul 23, 2020·Science·Yongfei CaiBing Chen
Jul 29, 2020·Frontiers in Immunology·Edison OngYongqun He
Aug 2, 2020·Nature Structural & Molecular Biology·Daming ZhouKuan-Ying A Huang
Aug 14, 2020·JAMA : the Journal of the American Medical Association·Shengli XiaXiaoming Yang
Aug 31, 2020·Lancet·Philip KrauseUNKNOWN World Health Organization Solidarity Vaccines Trial Expert Group
Sep 3, 2020·The New England Journal of Medicine·Cheryl KeechGregory M Glenn
Oct 15, 2020·The New England Journal of Medicine·Edward E WalshWilliam C Gruber
Oct 18, 2020·Nature Reviews. Microbiology·Shan SuShibo Jiang
Oct 29, 2020·The New England Journal of Medicine·Peter ChenUNKNOWN BLAZE-1 Investigators
Nov 10, 2020·Frontiers in Immunology·Omna SharmaChris R Triggle
Nov 29, 2020·Signal Transduction and Targeted Therapy·Zezhong LiuShibo Jiang
Dec 5, 2020·Nature·Katherine McMahanDan H Barouch
Dec 11, 2020·The New England Journal of Medicine·Fernando P PolackUNKNOWN C4591001 Clinical Trial Group
Dec 18, 2020·MedRxiv : the Preprint Server for Health Sciences·Kate M BubarDaniel B Larremore

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