COVID-19 vaccines: Knowing the unknown.

European Journal of Immunology
Huibin LvChris K P Mok

Abstract

Vaccine development against SARS-CoV-2 has drawn attention around the globe due to the exploding pandemic. Although COVID-19 is caused by a new coronavirus, SARS-CoV-2, previous research on other coronavirus vaccines, such as FIPV, SARS, and MERS, has provided valuable information for the rapid development of COVID-19 vaccine. However, important knowledge gaps remain - some are specific to SARS-CoV-2, others are fundamental to immunology and vaccinology. Here, we discuss areas that need to be addressed for COVID-19 vaccine development, and what can be learned from examples of vaccine development in the past. Since the beginning of the outbreak, the research progress on COVID-19 has been remarkable. We are therefore optimistic about the rapid development of COVID-19 vaccine.

References

May 14, 2010·Clinical and Vaccine Immunology : CVI·Stanley A Plotkin
Oct 30, 2010·Immunity·Robert L CoffmanRobert A Seder
Jan 8, 2013·Human Vaccines & Immunotherapeutics·Rebecca J Cox
Mar 30, 2013·Science·Joseph JardineWilliam R Schief
Mar 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jincun ZhaoStanley Perlman
Nov 10, 2015·Nature Medicine·Vineet D MenacheryRalph S Baric
Dec 25, 2015·Proceedings. Biological Sciences·A Katharina SimonAndrew McMichael
Feb 6, 2018·Nature Structural & Molecular Biology·Nicholas C Wu, Ian A Wilson
May 24, 2019·Frontiers in Immunology·Mark K Slifka, Ian J Amanna
Jul 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Katie L WinarskiSurender Khurana
Jul 19, 2019·Frontiers in Immunology·Tarra A Von Holle, M Anthony Moody
Aug 3, 2019·Science·Michelle C CrankUNKNOWN VRC 317 Study Team
Oct 12, 2019·Clinical and Experimental Dermatology·C QuinlanR Hughes
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 25, 2020·Emerging Microbes & Infections·Jianhui NieYouchun Wang
Mar 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jasper Fuk-Woo ChanKwok-Yung Yuen
Mar 29, 2020·JAMA : the Journal of the American Medical Association·Chenguang ShenLei Liu
Apr 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kai DuanXiaoming Yang
Apr 8, 2020·Cell Host & Microbe·Young-Il KimYoung Ki Choi
May 8, 2020·Nature·Linlin BaoChuan Qin
May 22, 2020·European Journal of Immunology·Virgil Schijns, Ed C Lavelle

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Citations

May 22, 2020·European Journal of Immunology·Virgil Schijns, Ed C Lavelle
Oct 27, 2020·Frontiers in Immunology·Morgan BrisseHinh Ly
Oct 30, 2020·Pharmacy : Journal of Pharmacy, Education and Practice·Lois LeeMary Bushell
Jun 6, 2021·International Journal of Dermatology·Robert S Shapiro
May 26, 2021·Scientific Reports·Poulami Majumder, Partha Pratim Ray
Jul 22, 2021·Biochemistry. Biokhimii︠a︡·Larisa V Kordyukova, Andrey V Shanko
Jul 1, 2021·ACS Sustainable Chemistry & Engineering·Agnieszka M Jastrzębska, Alexey S Vasilchenko

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