Cowden Syndrome

Journal of Genetic Counseling
C Eng


Cowden syndrome is an autosomal dominant inherited cancer syndrome characterized by multiple hamartomas which may develop in any organ. Mucocutaneous papillomas and trichilemmomas are hallmarks of the syndrome. Affected individuals are at high risk of developing both benign and malignant disease of the thyroid and breast. Epithelial thyroid carcinoma occurs in 3-10% of affected individuals while women have a 25-50% lifetime risk of developing adenocarcinoma of the breast. Because of the cancer risk, it is imperative that health care providers recognize Cowden syndrome. The susceptibility gene has been localized to 10q22-23 and preliminary studies demonstrate no genetic heterogeneity.


Jun 1, 1978·Cancer·M H BrownsteinJ B Bikowski
May 1, 1991·Annals of Neurology·G W PadbergF C de Beer
Jun 1, 1989·American Journal of Medical Genetics·F Halal, K Silver
Mar 1, 1986·Clinical Genetics·T M StarinkA W Eriksson
Aug 1, 1986·Journal of the American Academy of Dermatology·T M StarinkR Goldschmeding
Nov 1, 1993·Human Molecular Genetics·R BashirT Strachan
Feb 1, 1995·Journal of Medical Genetics·A M Hanssen, J P Fryns
Mar 1, 1994·Experimental Cell Research·H C TsouM Peacocke
Nov 1, 1993·Human Molecular Genetics·N CraddockJ Powell
Jul 1, 1993·Neurology·C J LyonsJ C Horton
May 1, 1996·Nature Genetics·M R NelenC Eng
Jan 1, 1963·Annals of Internal Medicine·K M LLOYD, M DENNIS

❮ Previous
Next ❯


Oct 1, 2003·American Journal of Medical Genetics. Part a·Charis Eng
Jul 21, 2004·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Anders Merg, James R Howe
Nov 30, 2006·Journal of Surgical Oncology·Francis D Moore
Jan 26, 2005·The American Journal of Gastroenterology·Ian Roy SchreibmanThomas J McGarrity
Mar 10, 2000·The American Journal of Gastroenterology·T J McGarrityR J Zaino
Nov 9, 2004·The Cancer Journal·Ellen T MatloffChristina M Chimera
Nov 9, 2010·Dermatologic Therapy·Melissa A Reyes, Daniel B Eisen
Jul 12, 2005·Diseases of the Colon and Rectum·Dae-Kyoum KimSung-Ae Jung
Jan 21, 2006·International Journal of Cancer. Journal International Du Cancer·Rosemary E TeresiCharis Eng
Mar 21, 2012·Head & Neck·Joseph E HallRobert J Sinard
Feb 8, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Stephanie Histed ChungMaitraya K Patel
Dec 20, 2002·The Oncologist·David MintzerDahlia Sataloff
Feb 3, 2004·The Oncologist·Darcy L Thull, Victor G Vogel
Aug 16, 2000·Current Opinion in Pediatrics·M A Parisi, V P Sybert
Aug 24, 2004·Oncogene·Rebecca NagyCharis Eng
Sep 27, 2000·Clinical Genetics·H Hampel, P Peltomaki
Nov 15, 2000·Clinical Genetics·R L Bennett
Aug 1, 1997·Nature Genetics·D J MarshC Eng
Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·A LaugéD Stoppa-Lyonnet
May 16, 2001·Annals of Surgical Oncology·D A WirtzfeldM A Rodriguez-Bigas
Jul 30, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T Papageorgiou, C A Stratakis
Feb 24, 2007·Journal of Genetic Counseling·Edenir Inez PalmeroLavinia Schüler-Faccini
Mar 21, 2013·American Journal of Medical Genetics. Part a·Anna VinitskyElizabeth W McPherson
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·M P MyersN K Tonks
Jun 8, 2001·Annual Review of Biochemistry·T MaehamaJ E Dixon
Jan 29, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takaaki SugiharaYoshikazu Murawaki
Oct 19, 2013·Journal of the National Cancer Institute·Katherine L Lachlan
Nov 27, 2016·Journal of Gastrointestinal Cancer·Mohamed AbdelfatahGlenn Harvin
Nov 24, 1999·Journal of the National Cancer Institute·I U AliM Dean
Aug 12, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Judith A Hobert, Charis Eng
Oct 31, 2008·Journal of Genetic Counseling·Robert Pilarski
Jun 4, 2013·Hereditary Cancer in Clinical Practice·Zoran StojcevAndrzej Plawski
Dec 1, 1998·Journal of Medical Genetics·M LongyD Bonneau
Jun 21, 2019·Cancers·Robert Pilarski
Jul 22, 1998·Journal of the National Cancer Institute·N M Lindor, M H Greene
Apr 18, 2015·Cancer Discovery·Satoshi KofujiTakehiko Sasaki
Mar 5, 2002·American Journal of Human Genetics·Kristin A Waite, Charis Eng
Aug 15, 2002·Cancer Letters·Deborah Marsh, Roberto Zori
Jun 29, 2021·Frontiers in Medicine·Agnes Lim, Joanne Ngeow

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.