Cow's Milk and Immune Function in the Respiratory Tract: Potential Mechanisms

Frontiers in Immunology
Olaf PerdijkR J Joost van Neerven

Abstract

During the last decades, the world has witnessed a dramatic increase in allergy prevalence. Epidemiological evidence shows that growing up on a farm is a protective factor, which is partly explained by the consumption of raw cow's milk. Indeed, recent studies show inverse associations between raw cow's milk consumption in early life and asthma, hay fever, and rhinitis. A similar association of raw cow's milk consumption with respiratory tract infections is recently found. In line with these findings, controlled studies in infants with milk components such as lactoferrin, milk fat globule membrane, and colostrum IgG have shown to reduce respiratory infections. However, for ethical reasons, it is not possible to conduct controlled studies with raw cow's milk in infants, so formal proof is lacking to date. Because viral respiratory tract infections and aeroallergen exposure in children may be causally linked to the development of asthma, it is of interest to investigate whether cow's milk components can modulate human immune function in the respiratory tract and via which mechanisms. Inhaled allergens and viruses trigger local immune responses in the upper airways in both nasal and oral lymphoid tissue. The components present in r...Continue Reading

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Citations

Apr 5, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Suzanne AbbringBetty C A M van Esch
Jun 20, 2019·Viruses·Chithra C SreenivasanFeng Li
Jan 9, 2019·Frontiers in Immunology·Pattraporn SatitsuksanoaMübeccel Akdis
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Dec 1, 2021·BMC Medicine·Mélanie Deschasaux-TanguyUNKNOWN SAPRIS-SERO study group

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