COX-1 and COX-2 polymorphisms in susceptibility to cerebral palsy in very preterm infants

Molecular Neurobiology
Helena Kapitanović VidakSanja Kapitanović

Abstract

Cerebral palsy (CP) is a nonprogressive motor disorder caused by white matter damage in the developing brain. Recent epidemiological and clinical data suggest intrauterine infection/inflammation as the most common cause of preterm delivery and neonatal complications, including CP. Cyclooxygenases are key enzymes in the conversion of arachidonic acid to prostaglandins. The COX family consists of two isoforms, COX-1 and COX-2. In the brain, COX-2 is constitutively expressed at high levels on pyramidal neurons, while COX-1 is predominantly expressed by microglia and can be upregulated in pathological conditions, such as infection, ischemia and traumatic brain injury. Single nucleotide polymorphisms in the COX-1 and COX-2 gene could have profound effects on COX-1 and COX-2 expression and, directly or indirectly, influence the pathogenesis, development and severity of CP. In this study we investigated the association between single nucleotide polymorphisms of the COX-1 and COX-2 gene and susceptibility to cerebral palsy in very preterm infants. The results of our study showed the association between COX-1 high expression genotype (-842 AA) and COX-1 high expression allele -842A and risk of CP in infants with cystic periventricular l...Continue Reading

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Citations

Nov 22, 2017·The European Journal of Neuroscience·Ravneet Rai-BhogalDorota A Crawford
Sep 2, 2017·Journal of Neuropathology and Experimental Neurology·Charanjit KaurEng-Ang Ling
Jun 17, 2020·Developmental Medicine and Child Neurology·Ryan PhamJesia G Berry
Jul 6, 2020·Cellular and Molecular Neurobiology·Yunfei XuJie Zhao
Feb 9, 2021·Frontiers in Neurology·Sara A LewisMichael C Kruer

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Methods Mentioned

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