Abstract
Recent studies have shown that diesel exhaust particles (DEP) have adverse effects on the respiratory tract in vitro and in vivo, related to various pro-inflammatory cytokines and inflammatory mediators. The inflammation induced by the production of cyclooxygenase (COX)-2, an important mediator of inflammation and tumor promotion, and excess eicosanoids may be central to the pathogenesis of DEP-induced airway inflammation. However, the role of COX-2 in the pathogenesis of DEP-induced lung inflammation remains unclear, especially in vivo. In this study, we demonstrated that treatment with 50 microg/ml of DEP for 24h induced the expression of the COX-2 gene at both the transcriptional and protein levels, which led to an increase in the release of prostaglandin E(2) (PGE(2)) in A549 cells. In addition, the increased levels of COX-2 and PGE(2) by DEP exposure were significantly suppressed by treatment with 50 pg/ml of dexamethasone (Dex). We also showed that exposure to 25 mg/kg of DEP induced the expression of the COX-2 protein in mouse lung tissues, and this increased COX-2 expression was attenuated by pretreatment with 5 mg/kg of Dex. These findings suggest that COX-2 may play an important role in the pathogenesis of DEP-induced...Continue Reading
Citations
Nov 26, 2013·Chemosphere·Laya BhavarajuMichael Madden
May 15, 2010·Archives of Toxicology·Damien van BerloRoel P F Schins
Jan 1, 2011·ISRN Toxicology·Junichi HosoyaMitsugu Maeno
Mar 26, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zhenlin WangYulu Li
Nov 21, 2012·Toxicology and Applied Pharmacology·Hsiao-Chi ChuangTsun-Jen Cheng
Nov 26, 2010·Toxicology Letters·Hemang PatelSoonjo Kwon
Jul 8, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jan I HersethPer E Schwarze
Apr 21, 2009·Toxicology Letters·Wakako Ridley, Masato Matsuoka
Sep 3, 2014·Particle and Fibre Toxicology·Michael C MaddenRobert B Devlin
Aug 21, 2015·International Journal of Cosmetic Science·M-A LefebvreL Nguyen
Feb 7, 2015·International Journal of Cosmetic Science·M-A LefebvreQ-L Nguyen
Oct 4, 2014·Journal of Dermatological Science·Jean KrutmannSophie Seite
Oct 28, 2014·PloS One·Zhonghai YanRachel L Miller
Oct 29, 2011·Toxicology and Industrial Health·Hasan TürkezMokhtar I Yousef
May 2, 2018·Biomolecules & Therapeutics·Jae-Hyoung SongHyun-Jeong Ko
May 4, 2011·Journal of Immunotoxicology·Tuya SharkhuuM Ian Gilmour
Aug 9, 2020·Journal of Applied Toxicology : JAT·Ludivine CanivetJ-M Lo Guidice
Jun 12, 2019·International Journal of Molecular Sciences·Francesca FarinaPaola Palestini
Jul 16, 2019·Biochemical and Biophysical Research Communications·Jiehao SunTianqi Zhu
Feb 3, 2021·Dermatologic Therapy·Ruhollah AbolhasaniReza M Robati
May 15, 2021·Bioinorganic Chemistry and Applications·Fen PengJian-Zhong Zhang
Mar 18, 2015·Journal of Agricultural and Food Chemistry·Shih-Ming Tsao, Mei-Chin Yin