COX-2 inhibition and colorectal cancer

Seminars in Oncology
Claus-Henning Koehne, R N DuBois

Abstract

Mortality in patients with advanced colorectal cancer(CRC) remains high. Epidemiologic studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs, including aspirin, have a significant reduction in CRC mortality, compared with those not taking these agents. The recent characterization of cyclooxygenase- I and -2 (COX- I and COX-2) isoforms has led to an expanded understanding of how nonsteroidal anti-inflammatory drugs may help prevent polyp formation. Cyclooxygenase enzymes are required for the conversion of arachidonic acid to prostaglandins.COX-2 mediates the inflammatory effects of COX activity, is induced by a wide spectrum of growth factors and proinflammatory cytokines, and is overexpressed in numerous premalignant and malignant lesions, including CRC. Treatment with the selective COX-2 inhibitor celecoxib has shown promising results in the prevention of CRC, Numerous studies show that this COX-2 selective inhibitor is a potent suppressor of colon polyps both in animal models for familial adenomatous polyposis and in patients with this condition. This has led to the US Food and Drug Administration approval of celecoxib for the treatment of patients with familial adenomatous polyposis. The rol...Continue Reading

References

Jan 1, 1989·American Journal of Surgery·W R WaddellR W Loughry
May 6, 1993·The New England Journal of Medicine·F M GiardielloG J Offerhaus
Dec 1, 1996·Gastroenterology Clinics of North America·R N DuBoisW E Smalley
May 1, 1997·The Journal of Clinical Investigation·H ShengR N DuBois
Feb 11, 2000·Annals of the New York Academy of Sciences·C WilliamsR N DuBois
Jun 7, 2000·The Journal of Clinical Investigation·C S WilliamsR N DuBois
Jun 30, 2000·The New England Journal of Medicine·G SteinbachG Kelloff
Mar 30, 2001·The Journal of Biological Chemistry·H ShengR N DuBois
Sep 22, 2001·Best Practice & Research. Clinical Gastroenterology·E Stack, R N DuBois

❮ Previous
Next ❯

Citations

Apr 13, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jin-Kyung KimJung Han Yoon Park
May 29, 2007·Journal of Gastroenterology·Takeyoshi ItsukumaHiroshi Hara
Sep 13, 2006·Cancer Metastasis Reviews·Alberto MantovaniAntonio Sica
Sep 17, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Eileen L HeinrichSteven M Dubinett
Feb 28, 2008·Cell Research·Michael Karin
Feb 17, 2006·The New England Journal of Medicine·Hans Clevers
Mar 14, 2009·Thyroid : Official Journal of the American Thyroid Association·Virginie QuidvilleSylvie Lausson
Sep 2, 2010·QJM : Monthly Journal of the Association of Physicians·H ConroyS C Donnelly
Nov 4, 2006·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Andres A Roma, Richard A Prayson
Aug 16, 2005·Gut·C R BolandA Goel
Jun 16, 2012·Journal of Biomedicine & Biotechnology·Carmine StolfiGiovanni Monteleone
Feb 18, 2009·Cancer Research·Alan P FieldsNicole R Murray
Mar 15, 2012·Cancer Research·Melody A SwartzYves A DeClerck
Oct 11, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Irfan M HisamuddinVincent W Yang
Apr 28, 2005·BMC Clinical Pharmacology·Simon K Mencher, Long G Wang
Mar 22, 2012·Annals of Surgical Oncology·Shinya IshimaruMasaki Mori
Aug 6, 2008·World Journal of Gastroenterology : WJG·Carmine StolfiGiovanni Monteleone
Sep 19, 2009·World Journal of Gastroenterology : WJG·Jun-Mei YeJian-Bao Zhang
Jul 17, 2014·Journal of Medicinal Food·Hee-Young KimKun-Young Park
Aug 23, 2005·Expert Review of Anticancer Therapy·Dimitris ZacharoulisStergios Zacharoulis
Jun 18, 2010·Expert Review of Anticancer Therapy·Cara K FraserJohn D Hayball
Dec 30, 2014·Journal of Cellular Physiology·Laurence BoothPaul Dent
Dec 20, 2011·Critical Reviews in Oncology/hematology·Olorunseun O Ogunwobi, Chen Liu
Jan 23, 2010·Brain, Behavior, and Immunity·Johan RuudAnders Blomqvist
Aug 16, 2005·Clinical Lung Cancer·Jenny T MaoSteven M Dubinett
Mar 8, 2008·Current Opinion in Genetics & Development·Paola AllavenaAlberto Mantovani
Feb 16, 2008·Lancet·Alberto MantovaniFrancesco M Marincola
Sep 4, 2007·The Breast : Official Journal of the European Society of Mastology·Alberto MantovaniPaola Allavena
Nov 10, 2007·Prostaglandins & Other Lipid Mediators·James A LinSrinivasa T Reddy
Jul 24, 2007·Prostaglandins & Other Lipid Mediators·Ajay NarasimhaSrinivasa T Reddy
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Yasushi TakiiKiyoshi Migita
Jul 28, 2011·NMR in Biomedicine·Ioannis StasinopoulosZaver M Bhujwalla
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Neta Erez, Lisa M Coussens
Mar 30, 2016·Cytokine & Growth Factor Reviews·Giorgio ManginoGiovanna Romeo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.