COX-2 inhibition in upper aerodigestive tract tumors

Seminars in Oncology
Nasser K AltorkiAndrew J Dannenberg

Abstract

Evidence continues to accumulate that cyclooxygenase-2 (COX-2), an inducible COX isoform, represents a potential pharmacological target for the prevention and treatment of cancer, including tumors affecting the entire upper aerodigestive tract. Studies in experimental models of these malignancies show that selective COX-1 inhibitors reduce tumor formation and growth. Clinical studies have been initiated to determine the chemoprotective effects of selective COX-2 inhibitors in patients with oral leukoplakia and Barrett's esophagus, and other studies are assessing the feasibility of incorporating these agents into existing treatment modalities for patients with locally advanced or metastatic cancer.

References

Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TsujiiR N DuBois
Mar 18, 1999·The New England Journal of Medicine·J LagergrenO Nyrén
Feb 13, 2001·Carcinogenesis·F W WieseF F Kadlubar
Mar 30, 2001·The Journal of Biological Chemistry·C H LiuT Hla
Apr 26, 2001·The Journal of Biological Chemistry·M DohadwalaS M Dubinett

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Citations

Feb 3, 2005·Nature Reviews. Cancer·Keith D HunterPaul R Harrison
Feb 22, 2008·Neuro-oncology·Stuart A GrossmanUNKNOWN New Approaches to Brain Tumor Therapy CNS Consortium
May 3, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nasser K AltorkiDavid S Schrump
Jul 27, 2010·Prostaglandins & Other Lipid Mediators·Sittichai KoontongkaewTheeranuch Saensuk
Jul 6, 2010·Experimental and Molecular Pathology·Silvia Maria Díaz PradoLuis Antón Aparicio
Feb 4, 2010·Cancer Treatment Reviews·Geoffrey Y Ku, David H Ilson
Nov 7, 2007·International Journal of Cancer. Journal International Du Cancer·Louise Y Y FongJohn L Farber
Nov 18, 2005·Nitric Oxide : Biology and Chemistry·Ning MaShosuke Kawanishi
Aug 15, 2006·Virchows Archiv : an International Journal of Pathology·Giuseppe PerroneCarla Rabitti
Jul 16, 2005·Journal of Internal Medicine·D Pereg, M Lishner
Mar 2, 2013·British Journal of Cancer·J C WilsonL A Anderson
Jan 24, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Guoming ChenHua Xu

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