PMID: 16507391Mar 2, 2006Paper

COX-2 inhibitors act as radiosensitizer in tumor treatment

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
P SminiaB Slotman

Abstract

Since cyclooxygenase-2 (COX-2) is overexpressed in malignant tissues, the COX-2 mediated signaling pathway has been recognized as potential target for therapeutic intervention. In most human tumors, COX-2 overexpression has been associated with tumor aggressiveness and poor clinical outcome. In vitro studies show inhibition of cell proliferation by selective COX-2 inhibitors alone, and enhancement of the response to irradiation. In vivo experimental reports demonstrate enhanced tumor response and impediment of tumor neovascularization following radiotherapy combined with COX-2 inhibition. Clinical studies on the combination of irradiation with COX-2 inhibitors are emerging. Taken together, the perspective for the combined approach of radiotherapy with COX-2 inhibition yields clinical significance since preclinical data demonstrate selective COX-2 inhibitors to act as radiosensitizer in tumor treatment.

References

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Citations

Sep 1, 2005·Journal of Cancer Research and Clinical Oncology·Peter SminiaBen J Slotman
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Y EddenM Berho
Nov 5, 2010·Journal of Translational Medicine·Wings T Y LooLouis W C Chow
Apr 24, 2010·The Oncologist·Deborah CitrinJames B Mitchell
Nov 23, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S-M CheL Hou
Jun 14, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Markus LaubeJens Pietzsch
Jun 9, 2006·Expert Review of Anticancer Therapy·Mark Luttjeboer, Gertjan J L Kaspers
Mar 4, 2020·International Journal of Oncology·Romina Gabriela ArmandoDaniel Eduardo Gomez
Feb 20, 2020·Cellular and Molecular Life Sciences : CMLS·Ehsan KhodamoradiBagher Farhood

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