COX-2 inhibitors are contraindicated for treatment of combined injury

Radiation Research
W JiaoG D Ledney

Abstract

Casualties of radiation dispersal devices, nuclear detonation or major ionizing radiation accidents, in addition to radiation exposure, may sustain physical and/or thermal trauma. Radiation exposure plus additional tissue trauma is known as combined injury. There are no definitive therapeutic agents. Cyclooxygenase-2 (COX-2), an inducible enzyme expressed in pathological disorders and radiation injury, plays an important role in inflammation and the production of cytokines and prostaglandin E(2) (PGE(2)) and could therefore affect the outcome for victims of combined injury. The COX-2 inhibitors celecoxib and meloxicam were evaluated for their therapeutic value against combined injury in mice. In survival studies, the COX-2 inhibitors had no beneficial effect on 30-day survival, wound healing or body weight gain after radiation injury alone or after combined injury. Meloxicam accelerated death in both wounded and combined injury mice. These drugs also induced severe hepatic toxicity, exaggerated inflammatory processes, and did not enhance hematopoietic cell regeneration. This study points to potential contraindications for use of COX-2 inhibitors in patients undergoing therapy for radiation injury and combined injury.

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Citations

Jun 13, 2012·Cell & Bioscience·Juliann G KiangG David Ledney
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Nov 20, 2014·Radiation Research·Janice A ZawaskiM Waleed Gaber
May 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferDenisa Komůrková
Nov 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferMartin Falk

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BETA
irradiate
ELISA

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