Cox-2-specific inhibitors: definition of a new therapeutic concept

American Journal of Therapeutics
Kenneth M VerburgP C Isakson


Nonsteroidal anti-inflammatory drugs have been a mainstay in the treatment of inflammatory diseases such as rheumatoid arthritis. However, these agents can result in severe and occasionally life-threatening adverse effects that can limit therapeutic benefit. Progress toward safer anti-inflammatory therapy was aided by the discovery that cyclooxygenase (COX) exists as two isozymes, COX-1 and COX-2. Both isozymes form prostaglandins that support physiologic functions; however, the formation of proinflammatory prostaglandins is catalyzed by COX-2. Inhibition of COX-2 accounts for the anti-inflammatory and analgesic action of NSAIDs; however, concurrent inhibition of COX-1 inhibits prostaglandin-dependent mechanisms such as gastroduodenal mucosal defense and platelet aggregation. This inhibition is the basis of the gastrointestinal toxicity and bleeding characteristic of these drugs. These findings led to the hypothesis that agents that selectively inhibit COX-2 would possess anti-inflammatory and analgesic action but would spare COX-1, thereby avoiding adverse effects in the gastrointestinal tract and platelets. Selective COX-2 inhibitors are now available. The novelty of these agents has raised questions in the medical community ...Continue Reading


Feb 1, 1978·The Journal of Clinical Investigation·J W BurchP W Majerus
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·L H Rome, W E Lands
Sep 10, 1992·The New England Journal of Medicine·M C AllisonR I Russell
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L MasferrerP Needleman
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M K O'BanionD A Young
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W L XieDaniel L Simmons
Jul 1, 1991·Journal of Clinical Pharmacology·A Whelton, C W Hamilton
May 17, 1991·The American Journal of Medicine·M C Houston
Jan 1, 1991·Archives of Internal Medicine·G BasheinG A Misbach
Feb 15, 1991·Annals of Internal Medicine·A H SollD McCarthy
Apr 1, 1991·Arthritis and Rheumatism·S H Roth
Aug 1, 1991·Annals of Internal Medicine·D P SandlerC R Weinberg
Oct 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N LaneD B Kimmel
Oct 1, 1990·The Journal of Clinical Investigation·J L MasferrerP Needleman
Jun 1, 1990·Journal of Clinical Gastroenterology·J H Kurata, D E Abbey
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A RazP Needleman
Dec 1, 1989·Arthritis and Rheumatism·W K Bernreuter
Apr 1, 1989·The American Journal of Medicine·R T Schoen, R J Vender
Mar 1, 1988·Hypertension·E G Erdös
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D L DeWitt, W L Smith
May 1, 1988·Clinical Pharmacology and Therapeutics·K A ConradP V Mayshar
Feb 22, 1988·The American Journal of Medicine·C J Shorrock, W D Rees
Jul 1, 1987·Kidney International·C Patrono, M J Dunn
Mar 1, 1986·Annals of Internal Medicine·D Y Graham, J L Smith
Dec 1, 1985·Circulation·C PatronoL Forni
Feb 1, 1974·American Journal of Obstetrics and Gynecology·M J NovyL Manaugh
Jun 23, 1971·Nature: New Biology·J B Smith, A L Willis
Aug 1, 1984·Scandinavian Journal of Haematology·S CronbergI Söderberg
Sep 1, 1981·Clinical Pharmacology and Therapeutics·D GreenC Ts'ao
Feb 1, 1982·American Journal of Surgery·L KitchenH Sideropoulos
Sep 1, 1982·The British Journal of Medical Psychology·H I MaghazajiM A Hmoud


Oct 24, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Alan F MerryChris Frampton
Jun 1, 2005·Biochimica Et Biophysica Acta·Tong Wu
Jul 10, 2003·Reproductive Toxicology·Franciszek BurdanLidia Klepacz
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Charles A BirbaraEtoricoxib Protocol 042 Study Group
Dec 14, 2002·Journal of Periodontology·Laurie K McCauley, Rahime M Nohutcu
Jan 9, 2007·Current Medical Research and Opinion·Jacques E ChellyAndrew M Tershakovec
May 18, 2010·Current Medical Research and Opinion·Tong J Gan
Sep 15, 2004·Trends in Parasitology·James P McCarter
Dec 13, 2005·Cancer Treatment Reviews·Tong Wu
Aug 19, 2003·The Annals of Pharmacotherapy·Margaret M VerricoAdele L Towers
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jing LengTong Wu
Apr 11, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ji-An ZhaoShi-Jie Wang
Apr 14, 2006·Journal of the American Animal Hospital Association·Adam D GasselSherry K Cox
Oct 5, 2006·Current Opinion in Anaesthesiology·T Samad, S Abdi
Oct 4, 2002·European Journal of Gastroenterology & Hepatology·David H SikesKenneth M Verburg
Nov 27, 2002·European Journal of Anaesthesiology. Supplement·D J Rowbotham
Apr 4, 2002·The Journal of the American Academy of Orthopaedic Surgeons·Joseph M Lane
May 11, 2002·The American Journal of the Medical Sciences·Robert W McMurray, Kenneth J Hardy

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Related Papers

The Veterinary Record
A Holliman, S P Scholes
Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
S K Kaan, C H Cho
© 2021 Meta ULC. All rights reserved